2'-OMe-PAC-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-O-methyl protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, 2'-O-methyl (OMe) oligo modifications display nuclease resistance, fewer off-target effects, and slightly increased hybridization affinities. These phosphoramidites are commonly used for oligos designed for antisense, siRNA, aptamer, or gRNA-based research. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 20-mL amber bottle with a serum vial neck style, which is compatible with most Applied Biosystems synthesizers and AKTA synthesizers.
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-N6-phenoxyacetyl-2'-O-methyl-adenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C49H56N7O9P
• Base Protection—PAC
• Formula weight—918.0 g/mol
• CAS number—128219-82-9
• HPLC purity—≥98.0%
• 31P NMR purity—≥98.0%