Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance
by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds
or hits specific to the full-length form
• Advance Parkinson's research
using the full-length protein and validated assaysRelated Links:LRRK2 Tools for Advancing Parkinson's Disease ResearchLanthaScreen® Kinase Activity AssayLanthaScreen® Eu Kinase Binding Assay