Invitrogen™

PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) Recombinant Human Protein

Catalog number: A31083
Invitrogen™

PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) Recombinant Human Protein

Catalog number: A31083
Catalog Number
A31083
Unit Size
20 µg
Price (USD)
Price: 788.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
Price: 2,255.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
Price: 7,010.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A3108320 µg
Price: 788.00
Your Price:
-
A32909100 µg
Price: 2,255.00
Your Price:
-
A333941 mg
Price: 7,010.00
Your Price:
-
Product Overview
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This PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein (full length) was expressed in insect cells. PIK3CA (E545K)/PIK3R1 lipid kinase (p110 alpha E545K/p85 alpha) consists of a 110 kDa catalytic subunit and an 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The PIK3CA catalytic subunit is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of PIK3CA is essential for vascular development and inactivation of PIK3Ca leads to severe defects in angiogenic sprouting and vascular remodeling. PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Specifications

Accession Number
PIK3CA E455K: NP_006209.2, PIK3R1(p110a) : NP_852664.1
Molecular Weight
125.4/84.7 kDa
Quantity
20 µg
KinaseFamily
PI3 Kinase
Protein Length
Full Length
Recombinant
Yes
Protein Tag
His Tag
Shipping Condition
Dry Ice
Expression System
Insect
Protein Form
Full Length, Recombinant, Active, Mutant
Form
Liquid
Validated Application
Kinase Assay
Species
Human

Contents & Storage

Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.