Invitrogen™

CDK4/cyclin D3 Recombinant Human Protein

Catalog number: A33736
Invitrogen™

CDK4/cyclin D3 Recombinant Human Protein

Catalog number: A33736
Catalog Number
A33736
Unit Size
1 mg
Price (USD)
Price: 7,010.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
10 µg
Price (USD)
Price: 480.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
Price: 2,240.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A337361 mg
Price: 7,010.00
Your Price:
-
A3351510 µg
Price: 480.00
Your Price:
-
A33573100 µg
Price: 2,240.00
Your Price:
-
Product Overview
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Additional Information
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Recommendations
This CDK4/cyclin D3 recombinant human protein (CDK4: full length, cyclin D3: full length) was expressed in insect cells. CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein. CDK4/cyclin D3 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

Specifications

Accession Number
CDK4: NP_000066.1, Cyclin D3: NP_001751.1
Molecular Weight
60.0/58.8 kDa
Quantity
1 mg
KinaseFamily
CDKs and CHKs
Protein Length
CDK4: Full Length, Cyclin D3: Full Length
Recombinant
Yes
Protein Tag
GST Tag
Shipping Condition
Dry Ice
Expression System
Insect
Protein Form
Full Length, Recombinant, Active
Form
Liquid
Validated Application
Kinase Assay
Species
Human

Contents & Storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol