Each lot of cryopreserved human hepatocytes is suitable for use in suspension metabolism applications and has been pharmacogenetically characterized as an homozygous null allele (e.g. CYP2D6*4⁄*4) via genotyping analysis (TaqMan®). The commonly tested Phase I (P450) and Phase II (UGT, SULT) drug metabolizing enzymes are analyzed for metabolic activity in each lot. Metabolite formation is measured by standard biochemical assays using LC-MS/MS or HPLC.Cells per vial:
9-12 millionGet the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes. Each lot is tested for:
•Phase I and II enzyme activities
•Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use. Related LinksLearn more about our cryopreserved hepatocytes Learn about our full line of hepatocytes
These products require shipment in LN2
vapor dewars therefore additional fees may apply.