Thermo Scientific™

Q Exactive™ Focus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

Catalog number: IQLAAEGAAPFALGMBHE
Thermo Scientific™

Q Exactive™ Focus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

Catalog number: IQLAAEGAAPFALGMBHE
The sensitivity, selectivity, flexibility, and ease-of-use provided by hybrid quadrupole-Orbitrap mass spectrometers set the standard for screening, quantitation, identification, and confirmation of targeted and untargeted compounds. The Thermo Scientific™ Q Exactive™ Focus hybrid quadrupole-Orbitrap MS makes this power accessible to environmental, food safety, clinical research, forensic toxicology, and pharmaceutical labs challenged by growing sample volumes and constrained by strict budgets. The Q Exactive Focus system simplifies method development, saving time and decreasing costs while reliably delivering unsurpassed results.
 
Catalog Number
IQLAAEGAAPFALGMBHE
Unit Size
Each
Scan Rates
Up to 12 Hz
Resolution
70,000 (at m/z 200)
Mass Range
50 to 3,000 m/z
Price (USD)
Full specifications
Mass Range50 to 3,000 m/z
TypeQuadrupole-Orbitrap LC-MS
Dynamic Range>5000:1
Mass AccuracyInternal: <1 ppm RMS; External: <3ppm RMS
Polarity SwitchingOne Full Cycle in <1 Sec (One Full Positive Mode Scan and One Full Negative Mode Scan (at a Resolution Setting of 35,000))
SensitivityFull MS: 500 fg Buspirone on Column S/N 100:1 SIM: 50 fg Buspirone on Column S/N 100:1
Resolution70,000 (at m/z 200)
Scan RatesUp to 12 Hz
Unit SizeEach
Showing 1 of 1
Catalog NumberSpecificationsUnit SizeScan RatesResolutionMass RangePrice (USD)
IQLAAEGAAPFALGMBHEFull specifications
EachUp to 12 Hz70,000 (at m/z 200)50 to 3,000 m/zRequest A Quote
Mass Range50 to 3,000 m/z
TypeQuadrupole-Orbitrap LC-MS
Dynamic Range>5000:1
Mass AccuracyInternal: <1 ppm RMS; External: <3ppm RMS
Polarity SwitchingOne Full Cycle in <1 Sec (One Full Positive Mode Scan and One Full Negative Mode Scan (at a Resolution Setting of 35,000))
SensitivityFull MS: 500 fg Buspirone on Column S/N 100:1 SIM: 50 fg Buspirone on Column S/N 100:1
Resolution70,000 (at m/z 200)
Scan RatesUp to 12 Hz
Unit SizeEach
Showing 1 of 1

Precision hardware

Thermo Scientific Ion Max API Source
  • H-ESI II probe with dual desolvation zone technology
  • Sweep gas to reduce chemical noise
  • 60° interchangeable ion probe orientation
  • Removable metal ion transfer capillary provides vent-free maintenance Vacuum System
  • Differentially pumped vacuum system with final vacuum <1 x 10⁻⁹
  • Two split-flow turbomolecular pumps and one rotary vane pump
  • Seven vacuum regions
Quadrupole Mass Filter
  • Thermo Scientific™ HyperQuad™ mass filter provides increased ion transmission
  • Variable precursor ion isolation width selection from 0.4 Da to full mass range
Ion Optics
  • RF lens stacked-ring radio frequency ion guide captures and efficiently focuses the ions into a tight beam. Large variable spacing between electrodes allows for better pumping efficiency and improved ruggedness.
  • Bent flatapole ion guide reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole
Orbitrap Mass Analyzer
  • Nitrogen-filled C-Trap
  • Highly efficient ion transfer to Thermo Scientific™ Orbitrap™ mass analyzer
  • Straight multipole collision cell for HCD
  • Orbitrap mass analyzer with 5 kV central electrode voltage
  • Low-noise image current preamplifier
  • 16-bit signal digitalization
Data Acquisition
  • Ultrafast real-time data acquisition and instrument control system
  • Fully automated calibration via instrument control software
  • Automatic Gain Control
Superior performance

The Q Exactive Focus mass spectrometer combines quadrupole precursor selection with high-resolution, accurate-mass detection to produce sensitivity that rivals triple quadrupole mass spectrometers and resolution that surpasses Q-TOF instruments.

  • Exceptional sensitivity thanks to superior selectivity that eliminates interferences allowing lower limits of detection and quantitation
  • Fast polarity switching so more classes of compounds can be processed in a single analysis
  • High scan speeds for compatibility with fast chromatography and high-throughput screening
  • Resolution superior to Q-TOF instruments for more confident identification and confirmation
  • Exceptionally wide linear dynamic range
Exceptional flexibility

The unique hybrid quadrupole-Orbitrap configuration provides exceptional flexibility, allowing Q Exactive Focus instruments to perform both targeted and untargeted screening with confident identification and confirmation. Q Exactive Focus instruments can take advantage of high-resolution, accurate-mass in a number of quantification approaches, including:

  • Full-scan – data-dependent MS/MS (FS-ddMS2) acquisition for ultimate scan speed and quantitative performance
  • *Variable data-independent acquisition (vDIA) for qualitative coverage for screening unknowns without compromising quantitative performance
  • Selected-ion monitoring (SIM) for simple setup and highest sensitivity
  • Parallel-reaction monitoring (PRM) for high selectivity and high throughput with confident confirmation
Powerful software

Application-specific software is available to make full use of the power of the Q Exactive Focus instrument. The system’s unique data acquisition function enables ultrafast real-time data acquisition and instrument control, fully automated calibration via instrument control software, and automatic gain control.

For component identification during targeted and untargeted analysis, the Thermo Scientific™ TraceFinder™ software includes libraries of high-resolution accurate-mass (HRAM) spectra. Compounds commonly targeted in food and environmental analyses, and in clinical research and forensic/toxicological studies, are represented by several thousand HRAM spectra. Combined with TraceFinder data analysis software, the Q Exactive Focus offers a powerful, yet simple-to-use solution for food safety, environmental, clinical research, forensic, and toxicological screening.

For research use only. Not for use in diagnostic procedures.
*vDIA method is not available in the United States