GeneBLAzer® D1-CRE-bla CHO-K1 cells contain the human Dopamine Receptor 1 (D1) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® D1-CRE-bla CHO-K1cells are functionally validated for Z' and EC50 concentrations of dihydrexidine. In addition, GeneBLAzer® D1-CRE-bla CHO-K1 DA cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
Agonists and antagonists of dopamine D1 receptors are in various stages of clinical trials for the treatment of neurological disorders like Parkinson's disease, Alzheimer's disease, schizophrenia, and psychosis.
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