GeneBLAzer® GPR54-NFAT-bla CHO-K1 cells contain the human KiSS1 receptor (GPR54) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer® GPR54-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Metastin. In addition, GeneBLAzer® GPR54-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The GPR54 receptor has been shown to be involved in tumor progression and metastasis, and in the development and functional regulation of the gonads.
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