The Tango™ TACR1-bla U2OS cells contain the human Tachykinin 1 (TACR1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ TACR1-bla U2OS cells are functionally validated for Z' and EC50 concentrations of (SAR9,MET(02)11)-Substance P. In addition, Tango™ TACR1-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
For Academic pricing please login or contact us at email@example.com.