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PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhhibition of PDHKs is viewed as a potential therapeutic treament for type II diabetes.
PDHK Kinase Family
Ser⁄Thr Kinases: Atypical
Contents & Storage
50 mM Tris pH 7.5, 150 mM NaCl, 0.02% Trition X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol.
Kinase proteins are shipped on dry ice. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.