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The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
NP_005219.2; T790M L858R
EGFR (ErbB1) T790M L858R
EGF Receptor (ErbB) Kinase Family
EGF (Epidermal Growth Factor)
Contents & Storage
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.