Informational:For order quantities > 1, multiple lots may be used to fulfill the order. If you require a single lot, please email firstname.lastname@example.org.
During checkout, this product will be reported as "Out of Stock" with an estimated availability date. Often, the actual availability date will be earlier. Send inquiries regarding actual availability date to email@example.com.
LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.