Thermo Scientific™

ACVR1 (ALK2) [R206H] Recombinant Human Protein

Catalog number: PV6233
Thermo Scientific™

ACVR1 (ALK2) [R206H] Recombinant Human Protein

Catalog number: PV6233
Catalog Number
PV6233
Unit Size
100 µg
Price (USD)
Price: 1,650.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
Price: 7,370.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV6233100 µg
Price: 1,650.00
Your Price:
-
PV62341 mg
Price: 7,370.00
Your Price:
-
Product Overview
Figures
Videos
Documents
FAQ
Citations & References
Additional Information
Recommendations
Recommendations
ACVR1 (ALK2) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ACVR1 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ACVR1 were predicted by protein structure homology modeling to activate the ACVR1 protein and enhance receptor signaling. Dysregulated ACVR1 kinase activity plays a role in the pathogenesis of FOP. Recombinant human ACVR1 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

Specifications

Molecular Weight
67.6 kDa
Quantity
100 µg
Gene Alias
ACVR1, FOP, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2
Protein Length
aa 147-end
Recombinant
Yes
Protein Tag
GST Tag
Kinase Group
Serine/Threonine Kinase
Expression System
Baculovirus
Protein Family
Growth Factors & Receptors
Protein Form
Recombinant
Form
Liquid
Validated Application
Kinase Assay
Species
Human

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.