Thermo Scientific™

LATS1 Recombinant Human Protein

Catalog number: PV6362
Thermo Scientific™

LATS1 Recombinant Human Protein

Catalog number: PV6362
Catalog Number
PV6362
Unit Size
100 µg
Price (USD)
Price: 1,644.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
10 µg
Price (USD)
Price: 483.00
Your Price:
Availability
-
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
Price: 7,370.00
Your Price:
Availability
-
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
PV6362100 µg
Price: 1,644.00
Your Price:
-
PV636110 µg
Price: 483.00
Your Price:
-
PV63631 mg
Price: 7,370.00
Your Price:
-
Product Overview
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Additional Information
Recommendations
Recommendations
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Related Product:
LanthaScreen® Eu Kinase Binding Assay

Specifications

Molecular Weight
89.4 kDa
Quantity
100 µg
Gene Alias
WARTS, wts
Protein Length
aa 589-end
Recombinant
Yes
Protein Tag
GST Tag
Kinase Group
Serine/Threonine Kinase
Expression System
Baculovirus
Protein Form
Recombinant
Form
Liquid
Validated Application
Kinase Assay
Species
Human

Contents & Storage

Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.