Extended Spectrum β Lactamases are enzymes capable of conferring bacterial resistance to penicillins, cephalosporins, and aztreonam by hydrolysis of these antibiotics 1,2
. Production of ESBLs is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae
and is a serious threat to the currently available antibiotic armory 3
Spectra ESBL Medium supports HAI surveillance programs through fast isolation and presumptive identification of ESBL-producing bacteria in clinical samples.
- Easy-to-read: clearly differentiates ESBL-producing organisms by their blue/turquoise-green or pink colonies.
- Facilitates early intervention: fast, accurate results support infection prevention and control.
- High specificity: reduces costs associated with unnecessary isolation and additional testing.
- Streamlined workflow: screen positive within 18 to 24 hours directly from perirectal swabs or fresh stool specimens.
- Ready-to-use: convenience of prepared media.
- First FDA-cleared chromogenic media for the presumptive identification of Proteus.
A mixture of chromogens forms a substrate for two enzymes: β-galactosidase and glucuronidase that are differentially expressed in different species of bacteria resulting in blue/turquoise-green or pink colonies. Other ESBL-producing organisms that do not utilize the chromogenic substrates may produce tan colonies through deamination of tryptophan. Non-target organisms generally appear cream colored or are naturally pigmented green or brown.
The main ESBL-producing bacteria include: Escherichia coli
, Klebsiella pneumoniae
, Klebsiella oxytoca
and Proteus mirabilis
. Accurate and rapid detection of ESBL-producing bacteria is essential to assist in the selection of appropriate antibiotic therapy, avoid treatment failures in patients, and prevent further transmission of these multi-drug-resistant organisms.4,5
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