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In this webinar, we present a unique LC-MS solution which offers versatile analytical workflows to meet forensic laboratory requirements for screening, quantitation, unknown identification and bulk substance analysis all in one high resolution Thermo Scientific™ Orbitrap™ platform. Targeted and universal screening workflows with retrospective data analysis capabilities will be discussed along with confirmatory quantitative methods utilizing parallel reaction monitoring experiment (PRM). Examples of unknown structure identification of a real-case designer drug and bulk substance analysis with a DART source will also be presented.