Cryo-ET Publications e-Book

Find structure and function with cryo-tomography

Cryo-Electron Tomography e-Book Preview

The interior of cells can be mysterious. Access the inner-workings of cells in 3D and at unprecedented nanoscale resolution using cryo-electron tomography. Cryo-electron tomography avoids the alterations caused by conventional chemical fixation and dehydration resulting in the imaging of cellular morphology and proteins under fully hydrated, near-native conditions. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity.

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Explore a curated collection of scientific publications highlighting the use of cryo-electron tomography including:

  • Endoplasmic reticulum-associated degradation machinery at distinct microsites near the ER
  • Discovery of ER sub-compartments known as ribosome-associated vesicles
  • Lewy bodies and neurites stuffed full of membranes, not protein filaments
  • In situ structure of Parkinson's disease-linked LRRK2
  • More reviews of articles from cell biology, neuroscience, microbiology, and virology

Prof. Ariane Briegel from Leiden University was plenary speaker at ASM Microbe 2019. She discusses how cryo-electron tomography is overcoming research barriers faced in microbiology and gives her top tips for working with the technology.

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