Since 2014, EU regulations have permitted gas chromatography–triple quadrupole mass spectrometry (GC–MS/MS) to be used as an alternative to GC–high resolution MS (GC–HRMS) for the control of maximum levels (MLs), action levels (ALs), and confirmatory analysis of dioxins and dioxin-like compounds in food and feed samples. Even though the utilization of GC–MS/MS for this application has been shown in principle, there is a lack of robust data to validate the suitability of this technique, especially for the long-term routine analysis of hundreds of samples, of different types, and with full compliance of quality performance criteria at the low pg/g concentrations. In addition to the deficiencies in validation data, there is a need for software packages to deal with the complexities of the calculations required to process and report data using isotopic dilution. This webcast illustrates the development and capability of a new Dioxin Analyzer using Advanced Electron Ionization (AEI) for ultra-high sensitivity to deliver:
- Successful validation of method performance criteria (LOQ, precision, accuracy, and calibration) at values as low as 0.15 (for a 2 g sample intake weight) expressed as upper-bound WHO-PCDD/F-TEQ (pg/g), meeting the 1/5th maximum level requirements
- Maximum uptime and sample throughput ensured by minimizing maintenance required (such as source cleaning, liner replacement, tuning, or analytical column trimming) even for batch sequences running continuously for two weeks
- Simplifying the user experience using an integrated software platform with the ability to automatically setup, seamlessly acquire, process and report compliant data in a fully regulated environment
