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        Dioxin Analysis with Triple Quadrupole GC-MS/MS: How to Simplify Complexity While Ensuring Compliance with the Latest EU Regulations

        • Overview
        • About the presenters

        Since 2014, EU regulations have permitted gas chromatography–triple quadrupole mass spectrometry (GC–MS/MS) to be used as an alternative to GC–high resolution MS (GC–HRMS) for the control of maximum levels (MLs), action levels (ALs), and confirmatory analysis of dioxins and dioxin-like compounds in food and feed samples. Even though the utilization of GC–MS/MS for this application has been shown in principle, there is a lack of robust data to validate the suitability of this technique, especially for the long-term routine analysis of hundreds of samples, of different types, and with full compliance of quality performance criteria at the low pg/g concentrations. In addition to the deficiencies in validation data, there is a need for software packages to deal with the complexities of the calculations required to process and report data using isotopic dilution. This webcast illustrates the development and capability of a new Dioxin Analyzer using Advanced Electron Ionization (AEI) for ultra-high sensitivity to deliver:

        • Successful validation of method performance criteria (LOQ, precision, accuracy, and calibration) at values as low as 0.15 (for a 2 g sample intake weight) expressed as upper-bound WHO-PCDD/F-TEQ (pg/g), meeting the 1/5th maximum level requirements
        • Maximum uptime and sample throughput ensured by minimizing maintenance required (such as source cleaning, liner replacement, tuning, or analytical column trimming) even for batch sequences running continuously for two weeks
        • Simplifying the user experience using an integrated software platform with the ability to automatically setup, seamlessly acquire, process and report compliant data in a fully regulated environment

        Key learning objectives:

        • Discover a fully integrated dioxin analyzer with pre-loaded acquisition, calculation and reporting templates that simplifies user training and enables increased productivity soon after installation
        • Learn how this analytical method is easily implemented into laboratories and able to monitor EU performance criteria to support the validity of data generated for dioxin analysis
        • Understand how GC–MS/MS with enhanced sensitivity enables users to lower sample weights, reducing both the cost of sample preparation and system maintenance

        Who should attend:

        • Analysts and lab managers in reference and contract testing laboratories
        • Scientists and chemists at the government agencies, universities and food manufacturers
        • Analysts performing dioxin analysis using GC–HRMS
        Richard Law, Senior Applications Specialist, Thermo Fisher Scientific

        Richard Law, Senior Applications Specialist, Thermo Fisher Scientific

        Richard is a Senior Applications Specialist working in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific, Runcorn, UK. Richard is an experienced analytical chemist and mass spectrometrist responsible for application and method development using various GC-MS technology, in particular GC-MS/MS. Richard has worked in industry gaining strong hands-on experience with GC-MS systems used to investigate trace chemicals in environmental and industrial applications.

        Fausto Pigozzo, Director of Workflow Development, Thermo Fisher Scientific

        Fausto Pigozzo, Director of Workflow Development, Thermo Fisher Scientific

        Fausto Pigozzo is the Director of Workflow Development, Food and Beverage in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific. With over 25 years of experience in analytical chemistry and mass spectrometers, Fausto has contributed to the development of all GC and GC-MS and ancillary devices offered today by Thermo Fisher Scientific.

        Overview

        Since 2014, EU regulations have permitted gas chromatography–triple quadrupole mass spectrometry (GC–MS/MS) to be used as an alternative to GC–high resolution MS (GC–HRMS) for the control of maximum levels (MLs), action levels (ALs), and confirmatory analysis of dioxins and dioxin-like compounds in food and feed samples. Even though the utilization of GC–MS/MS for this application has been shown in principle, there is a lack of robust data to validate the suitability of this technique, especially for the long-term routine analysis of hundreds of samples, of different types, and with full compliance of quality performance criteria at the low pg/g concentrations. In addition to the deficiencies in validation data, there is a need for software packages to deal with the complexities of the calculations required to process and report data using isotopic dilution. This webcast illustrates the development and capability of a new Dioxin Analyzer using Advanced Electron Ionization (AEI) for ultra-high sensitivity to deliver:

        • Successful validation of method performance criteria (LOQ, precision, accuracy, and calibration) at values as low as 0.15 (for a 2 g sample intake weight) expressed as upper-bound WHO-PCDD/F-TEQ (pg/g), meeting the 1/5th maximum level requirements
        • Maximum uptime and sample throughput ensured by minimizing maintenance required (such as source cleaning, liner replacement, tuning, or analytical column trimming) even for batch sequences running continuously for two weeks
        • Simplifying the user experience using an integrated software platform with the ability to automatically setup, seamlessly acquire, process and report compliant data in a fully regulated environment

        Key learning objectives:

        • Discover a fully integrated dioxin analyzer with pre-loaded acquisition, calculation and reporting templates that simplifies user training and enables increased productivity soon after installation
        • Learn how this analytical method is easily implemented into laboratories and able to monitor EU performance criteria to support the validity of data generated for dioxin analysis
        • Understand how GC–MS/MS with enhanced sensitivity enables users to lower sample weights, reducing both the cost of sample preparation and system maintenance

        Who should attend:

        • Analysts and lab managers in reference and contract testing laboratories
        • Scientists and chemists at the government agencies, universities and food manufacturers
        • Analysts performing dioxin analysis using GC–HRMS
        About the presenters
        Richard Law, Senior Applications Specialist, Thermo Fisher Scientific

        Richard Law, Senior Applications Specialist, Thermo Fisher Scientific

        Richard is a Senior Applications Specialist working in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific, Runcorn, UK. Richard is an experienced analytical chemist and mass spectrometrist responsible for application and method development using various GC-MS technology, in particular GC-MS/MS. Richard has worked in industry gaining strong hands-on experience with GC-MS systems used to investigate trace chemicals in environmental and industrial applications.

        Fausto Pigozzo, Director of Workflow Development, Thermo Fisher Scientific

        Fausto Pigozzo, Director of Workflow Development, Thermo Fisher Scientific

        Fausto Pigozzo is the Director of Workflow Development, Food and Beverage in the Chromatography and Mass Spectrometry Division at Thermo Fisher Scientific. With over 25 years of experience in analytical chemistry and mass spectrometers, Fausto has contributed to the development of all GC and GC-MS and ancillary devices offered today by Thermo Fisher Scientific.

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