Due to technological advances in imaging, bacteria and archaea can no longer be viewed as mainly undifferentiated sacs of jumbled enzymes. Methods such as cryo-electron tomography (cryo-ET) have given rise to a much more beautifully complicated view of prokaryotic cells. Finer and finer details of microbial cell biology reveal organized assemblies of macromolecular machines that are optimized to travel through and interact with complex and dynamic environments. These fascinating observations raise a number of unanswered questions for unchartered discovery.
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