Thermo Fisher Scientific
DNA methylation is a fundamental biochemical process that occurs in every tissue and organ system in the body. The study of this process helps researchers identify potential biomarkers and understand how the function of the genetic sequence is implemented and regulated. DNA Methylation is widely studied for its association with cancer, autoimmune disorders and other complex diseases such as Alzheimer’s disease.
Next-generation sequencing (NGS) enables high-throughput sequencing, mapping, and counting of short DNA reads (tags). In combination with traditional methylation profiling strategies (bisulfite conversion, digestion with methylation-sensitive restriction enzymes, and antibodyor 5-methylcytosine binding protein–based purification), NGS can be used for comprehensive, genome-wide mapping of methylation sites.
With Ion Torrent focused next-generation sequencing (NGS) technology, you get the speed, scalability and precision you need so that you can spend more time finding answers and less time looking for them. Further your epigenetics research with our comprehensive NGS solution, which enables a complete, targeted 3-day* workflow for quantitative methylation analysis across multiple loci when combined with the bisulfite conversion method.
Read our poster from AGBT 2019: The first low input, three-day NGS Ion AmpliSeq Methylation Panel and protocol
Our latest Ion AmpliSeq Methylation Panel for Cancer Research leverages leading molecular biology and targeted sequencing technologies:
Complete the form at right and a sales representative will reach out to you to discuss project costs and how this solution can be incorporated into your existing NGS workflow.
Next-generation sequencing (NGS) can be used for comprehensive, genome-wide mapping of methylation sites, thus enhancing the efficiency of DNA methylation research projects.
Fill out the form below and a sales representative will get in touch with you to discuss project costs and how this solution can be incorporated into your existing NGS workflow.
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* 3-day workflow from DNA to data using the bisulfite conversion method on Ion GeneStudio™ systems with the Ion 530™ Chip.
For Research Use Only. Not for use in diagnostic procedures.