A rapid, effective, economical path to a clean extract
Solid phase extraction (SPE) is a sample preparation technique that chromatographers use to remove interfering compounds, concentrate the analyte, and/or extract the analyte in a preferred solvent prior to HPLC, GC, IC, or MS analysis.
Remove uncertainty and add consistency to your chromatographic results using Thermo Scientific solid phase extraction products. Our broad range of high performance SPE products:
- Reduce the adverse effects of the sample matrix
- Significantly improve the robustness, reproducibility, and sensitivity of chromatographic and mass spectrometry analytical results
Choosing your SPE solution
Download our solid-phase extraction (SPE) phases solutions poster and learn about our polymerics, reversed-phase silica, normal phase silica ion-exchange phases options.
- Your comprehensive SPE solution
- 20 phases to choose from
- Bed weights from 1mg–10g; volumes from 1mL–75mL
- Designed for high throughput, low-volume samples such as bioanalysis
- Reduced sample failures and higher reproducibility with viscous biological samples
- 5 phases important to bioanalysis
- Unique SPE tips to prepare samples as low as 100nL with minimal sample loss
- A range of stationary phases for a wide range of applications
- Perform SPE online and inject sample directly onto HPLC column
- Integrated sample preparation and pre-concentration
- Compatible with conventional HPLC systems
- Available in a range of formats
- For use in processing multiple samples
- Cartridges or 96-well plates
Guide to solid phase extraction (SPE)
New to SPE sample preparation? Visit the pages below to learn about solid phase extraction, and if you need to develop, optimize, or troubleshoot your method.
- How SPE works
- Overview of SPE steps
- SPE cartridges and 96 well plates
- About Thermo Scientific SPE cartridge and plates
- Manifolds for SPE sample processing
- Overview of SPE phases
- SPE phase selection flow chart
- Choosing the correct SPE format and bed weight
- Recommended solvents to use in SPE
- SPE phase and solvent selection
- SPE method development
- SPE Method optimization
- Online SPE and other forms of SPE
- Glossary
- Poor recovery of analytes from SPE
- Analytes not eluted from SPE column
- Inconsistent extraction
- Interferences eluting with analyte
- Slow Column Flow Rate
- Large volume of sample required
- Low throughput
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