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Now you can go beyond faster to biological discoveries
- Analyze how cellular heterogeneity affects the biological system
- Identify and characterize rare cell types and limited samples
- Identify and quantify proteins with greater depth and coverage in a single cell
- Maximize sensitivity with the Thermo Scientific FAIMS Pro Interface
- Enhance sensitivity and throughput by multiplexing cells with TMT isobaric labeling
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Challenges and Emerging Directions in Single-Cell Proteomics
Will It Go Mainstream Like Genomics?
Proteomics has seen many advances over the last decade from improvements in mass spectrometry instrumentation to an expansion of new workflows and applications. The promise of single-cell proteomics has been a topic frequently discussed over the last 10 years, with the hope it becomes a reality.
Download the white paper to learn about the challenges of single-cell proteomics, new technologies that address these challenges, improvements and the outlook for single-cell proteomics.
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One cell at a time:
Single cell proteomics becomes a reality
Dr. Ryan Kelly, Associate professor, Chemistry and Biochemistry, Brigham Young University.
Multiplexed single cell proteomics:
A marriage of sensitivity and throughput
Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University
Using single-cell proteomics
and transcriptomics to understand gene regulation
Nikolai Slavov, Assistant Professor
Allen Distinguished Investigator, Bioengineering Department and Barnett Institute, Northeastern University
One cell at a time:
Single cell proteomics becomes a reality
Dr. Ryan Kelly, Associate professor, Chemistry and Biochemistry, Brigham Young University.
Multiplexed single cell proteomics:
A marriage of sensitivity and throughput
Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University
Using single-cell proteomics
and transcriptomics to understand gene regulation
Nikolai Slavov, Assistant Professor
Allen Distinguished Investigator, Bioengineering Department and Barnett Institute, Northeastern University
Sensitive and high-throughput single-cell proteomics workflow on new quadrupole-ion trap-orbitrap mass spectrometer with FAIMS separation
Presented at ASMS 2020
High-throughput single cell proteomics analysis with nanodroplet sample processing, multiplex TMT labeling and ultra-sensitive LC/MS
Label-Free Proteomics Performance with the Orbitrap Exploris 480 Mass Spectrometer with Single-Cell Sensitivity
Ultra-Sensitive LC-MS Workflow for In-Depth Label-Free Analysis of Single Mammalian Cells with Nanodroplet Sample Processing
Orbitrap Exploris 480 Mass Spectrometer
Obtain maximum quantitative insights with industry-leading single-cell sensitivity and extraordinary accuracy, precision and simplicity. With curated workflows that deliver greater usability, the Thermo Scientific Orbitrap Exploris 480 mass spectrometer accelerates your path to large scale studies, delivering maximum insights from limited samples and single-cells, with proven high data quality and time savings, so you can go beyond faster to actionable outcomes.
Orbitrap Eclipse Tribrid Mass Spectrometer
With innovations that deliver maximum sensitivity and throughput, the Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer allows you to move away from bulk sample to rare cell and single-cell proteomics analysis. In combination with TMT multiplexing reagents and the FAIMS Pro Interface, we deliver more proteins per cell, profiling and quantifying proteins from tens to hundreds of cells per day, generating maximum insights that assess cell heterogeneity and rare cell type, so you can go beyond faster to biological discoveries.
FAIMS Pro Interface
Achieve superior selectivity and enable more proteins to be identified while reducing time-consuming sample preparation steps with the next generation differential ion mobility Thermo Scientific FAIMS Pro interface. It reduces singly charged chemical noise and matrix interferences, resulting in the enhancement of peptide ions maximizing the sensitivity needed for single cell proteomics analysis.
TMTpro 16plex Label Reagent Set
Thermo Scientific Tandem Mass Tag Reagents are designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry. To increase throughput for single-cell proteomics analysis, the new TMTpro 16plex label reagent set delivers the ability to analyze more than 100 single cells per day per HRAM Tribrid MS instrument with the use of a booster channel to maximize sensitivity needed for single-cell analysis.
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