LanthaScreen™ fluorescent coregulator peptides for nuclear receptors contain known interaction motifs and are labeled with fluorescein.

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Peptide 100 μl Sequence Description
SRC1-1PV4576KYSQTSHKLV-
QLLTTTAEQQL		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-2PV4578LTARHKILHR-
LLQEGSPSD		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-3PV4580ESKDHQLLR-
YLLDKDEKDL		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-4PV4582GPQTPQAQQ-
KSLLQQLLTE		Peptide contains the nuclear receptor box4 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC2-1PV4584DSKGQTKLLQ-
LLTTKSDQM		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-2PV4586LKEKHKILHRLL-
QDSSSPV		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-3PV4588KKKENALLRYLL-
DKDDTKD		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC3-1PV4590ESKGHKKLLQ-
LLTCSSDDR		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-2PV4592LQEKHRILHK-
LLQNGNSPA		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-3PV4594KKENNALLRY-
LLDRDDPSD		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
CBP-1PV4596AASKHKQLSE-
LLRGGSGSS		This peptide contains the LXXLL motif 1 of CREB binding protein and is involved in ligand-dependent nuclear receptor interactions.4
TRAP220/DRIP-1PV4598KVSQNPILT-
SLLQITGNGG		This peptide is the LXXLL motif 1 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
TRAP220/DRIP-2PV4549NTKNHPML-
MNLLKDNPAQD		This peptide is the LXXLL motif 2 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
RIP140 L6PV4600SHQKVTLLQ-
LLLGHKNEEN		This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 6, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
RIP140 L8PV4602SFSKNGLLS-
RLLRQNQDSY		This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 8, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
PGC1aPV4421EAEEPSLLK-
KLLLAPANTQ		This peptide is derived from the PPARg coactivator protein 1a and contains an LXXLL motif.7
PRIP/RAP250PV4604VTLTSPLLVNL-
LQSDISAG		This peptide contains the LXXLL-interaction motif of the PPAR interacting protein, PRIP.4
D22PV4386LPYEGSLLLK-
LLRAPVEEV		Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, RIP140, PCG-1, DAX-1, and SHP.8
C33PV4606HVEMHPLLMG-
LLMESQWGA		Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, TRAP220 and RIP140.8
EAB1PV4608SSNHQSSR-
LIELLSR		Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.9
EA2PV4610SSKGVLWRM-
LAEPVSR		Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.10
TB3PV4614SSVASREW-
WVRELSR		Peptide was discovered by random phage display during tamoxifen-induced interactions with ER.10
AR(16-34)PV4616SKTYRGAFQ-
NLFQSVREVI		This peptide is the N-terminal sequence of AR which mediates a ligand-induced intradomain interaction with the ligand binding domain.11
ARA70PV4618SRETSEKFKL-
LFQSYNVND		This peptide is the FxxLF motif of the AR-specific coactivator, ARA70.11
D11 FxxLFPV4382VESGSSRFM-
QLFMANDLLT		This random phage display peptide had been modified to contain the AR-specific FxxLF interaction motif.11
SMRT ID1PV4620GHQRVVTLA-
QHISEVITQDYTRH		This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
SMRT ID2PV4423HASTNMGLEA-
IIRKALMGKYDQW		This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
NCoR ID1PV4622RTHLITLADH-
ICQIITQDFARN		This peptide contains motif 1 of the Nuclear CoRepressor protein.13
NCoR ID2PV4624DPASNLGLEDII-
RKALMGSFDDK		This peptide contains motif 2 of the Nuclear CoRepressor protein.13

References

  • Onate SA, Tsai SY, Tsai MJ, O’Malley BW (1995) Science 270:1354-1357
  • Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW (1996) Endocrinology 137: 3594-3597.
  • Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997) Science 277:965-968.
  • Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson J-A (2000) J Biol Chem 275:5308-5317.
  • Rachez C, Gamble M, Chang C-PB, Atkins GB, Lazar MA, Freedman LP (2000) Mol Cell Biol 20:2718-2726.
  • Cavailles V, Dauvois S, L’Horset F, Lopez F, Hoare S, Kushner PJ, Parker MG (1995) EMBO J. 14:3741-3751.
  • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) Cell 92: 829-839
  • Chang CY, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, McDonnell DP (1999) Mol Cell Biol 19:8226-8239.
  • Norris JD, Paige LA, Christensen DJ, Chang CY, Huacani MR, Fan D, Hamilton PT, Fowlkes DM, McDonnell DP (1999) Science 285:744-746.
  • Heldring N, Nilsson M, Buehrer B, Trueter E, Gustafsson J-A (2004) Mol Cell Biol 24:3445-3459.
  • He B, Minges JT, Lee LW, Wilson EM (2002) J Biol Chem 277:10226-10235.
  • Chen JD, Evans RM (1995) Nature 377:454-457.
  • Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Genes Dev 13:3198-3208.
Product Selection Table
Peptide 100 μl Sequence Description
SRC1-1PV4576KYSQTSHKLV-
QLLTTTAEQQL		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-2PV4578LTARHKILHR-
LLQEGSPSD		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-3PV4580ESKDHQLLR-
YLLDKDEKDL		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-4PV4582GPQTPQAQQ-
KSLLQQLLTE		Peptide contains the nuclear receptor box4 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC2-1PV4584DSKGQTKLLQ-
LLTTKSDQM		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-2PV4586LKEKHKILHRLL-
QDSSSPV		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-3PV4588KKKENALLRYLL-
DKDDTKD		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC3-1PV4590ESKGHKKLLQ-
LLTCSSDDR		Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-2PV4592LQEKHRILHK-
LLQNGNSPA		Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-3PV4594KKENNALLRY-
LLDRDDPSD		Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
CBP-1PV4596AASKHKQLSE-
LLRGGSGSS		This peptide contains the LXXLL motif 1 of CREB binding protein and is involved in ligand-dependent nuclear receptor interactions.4
TRAP220/DRIP-1PV4598KVSQNPILT-
SLLQITGNGG		This peptide is the LXXLL motif 1 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
TRAP220/DRIP-2PV4549NTKNHPML-
MNLLKDNPAQD		This peptide is the LXXLL motif 2 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
RIP140 L6PV4600SHQKVTLLQ-
LLLGHKNEEN		This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 6, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
RIP140 L8PV4602SFSKNGLLS-
RLLRQNQDSY		This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 8, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
PGC1aPV4421EAEEPSLLK-
KLLLAPANTQ		This peptide is derived from the PPARg coactivator protein 1a and contains an LXXLL motif.7
PRIP/RAP250PV4604VTLTSPLLVNL-
LQSDISAG		This peptide contains the LXXLL-interaction motif of the PPAR interacting protein, PRIP.4
D22PV4386LPYEGSLLLK-
LLRAPVEEV		Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, RIP140, PCG-1, DAX-1, and SHP.8
C33PV4606HVEMHPLLMG-
LLMESQWGA		Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, TRAP220 and RIP140.8
EAB1PV4608SSNHQSSR-
LIELLSR		Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.9
EA2PV4610SSKGVLWRM-
LAEPVSR		Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.10
TB3PV4614SSVASREW-
WVRELSR		Peptide was discovered by random phage display during tamoxifen-induced interactions with ER.10
AR(16-34)PV4616SKTYRGAFQ-
NLFQSVREVI		This peptide is the N-terminal sequence of AR which mediates a ligand-induced intradomain interaction with the ligand binding domain.11
ARA70PV4618SRETSEKFKL-
LFQSYNVND		This peptide is the FxxLF motif of the AR-specific coactivator, ARA70.11
D11 FxxLFPV4382VESGSSRFM-
QLFMANDLLT		This random phage display peptide had been modified to contain the AR-specific FxxLF interaction motif.11
SMRT ID1PV4620GHQRVVTLA-
QHISEVITQDYTRH		This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
SMRT ID2PV4423HASTNMGLEA-
IIRKALMGKYDQW		This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
NCoR ID1PV4622RTHLITLADH-
ICQIITQDFARN		This peptide contains motif 1 of the Nuclear CoRepressor protein.13
NCoR ID2PV4624DPASNLGLEDII-
RKALMGSFDDK		This peptide contains motif 2 of the Nuclear CoRepressor protein.13
References

References

  • Onate SA, Tsai SY, Tsai MJ, O’Malley BW (1995) Science 270:1354-1357
  • Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW (1996) Endocrinology 137: 3594-3597.
  • Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997) Science 277:965-968.
  • Caira F, Antonson P, Pelto-Huikko M, Treuter E, Gustafsson J-A (2000) J Biol Chem 275:5308-5317.
  • Rachez C, Gamble M, Chang C-PB, Atkins GB, Lazar MA, Freedman LP (2000) Mol Cell Biol 20:2718-2726.
  • Cavailles V, Dauvois S, L’Horset F, Lopez F, Hoare S, Kushner PJ, Parker MG (1995) EMBO J. 14:3741-3751.
  • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) Cell 92: 829-839
  • Chang CY, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, McDonnell DP (1999) Mol Cell Biol 19:8226-8239.
  • Norris JD, Paige LA, Christensen DJ, Chang CY, Huacani MR, Fan D, Hamilton PT, Fowlkes DM, McDonnell DP (1999) Science 285:744-746.
  • Heldring N, Nilsson M, Buehrer B, Trueter E, Gustafsson J-A (2004) Mol Cell Biol 24:3445-3459.
  • He B, Minges JT, Lee LW, Wilson EM (2002) J Biol Chem 277:10226-10235.
  • Chen JD, Evans RM (1995) Nature 377:454-457.
  • Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Genes Dev 13:3198-3208.

For research use only. Not intended for any animal or human therapeutic or diagnostic use.

For Research Use Only. Not for use in diagnostic procedures.

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