H9 cells grown on Geltrex hESC-qualified Ready-To-Use Matrix and Essential 8 Medium, stained for Tra-1-81 expression

Culturing cells on flat plasticware surfaces results in artificial two-dimensional sheets of cells. Normal cells in the human body experience a three-dimensional environment, completely surrounded by other cells, membranes, fibrous layers, and adhesion proteins.

Our Gibco products including extracellular matrices, scaffolds and proteins provide in vivo–like morphology and physiologically relevant environments for more realistic cell biology and better intercellular interactions.

Gibco Human Spheroid-Qualified Hepatocytes

See how our collagen products enable 3D research with Gibco Spheroid-qualified hepatocytes.
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Geltrex products are free of the lactate dehydrogenase-elevating virus (LDEV) making them ideal for all types of cell culture and mouse in vivo research.


Laminin is the major glycoprotein component of basement membranes. Mouse Laminin facilitates the attachment and expansion of ESCs, iPSCs and NSCs.


Collagen is the most widely used extracellular matrix protein for cell culture, facilitating cell attachment, growth, differentiation, migration, and tissue morphogenesis.


Poly-D-Lysine (PDL) is a synthetic extracellular matrix widely used to promote cell adhesion of a variety of cell types. PDL is also ideal for finicky cells, such as primary and PSC-derived neurons.


Vitronectin (VTN-N) is a recombinant human protein that provides a defined surface for feeder-free culture of human pluripotent stem cells (PSCs). It was designed for use with Essential 8 Medium and has been proven to maintain pluripotency and normal growth characteristics in multiple PSC lines.

Other matrix proteins

Other popular extracellular matrix proteins

3D cell culture systems