Viral RNA/DNA Purification

Sample preparation solutions for extracting and purifying viral RNA and DNA

Viral analysis of biological and environmental samples requires rapid and efficient purification of high-quality viral nucleic acids from various sample types. We are a leading supplier of the most successful tools used for viral RNA and DNA purification.

Magnetic bead viral RNA/DNA purification

The following products are recommended for viral nucleic acid isolation for SARS-CoV-2.

Dynabeads Intact Virus Enrichment

Launched in 2021, the Dynabeads Intact Virus Enrichment kit is optimized for SARS‑CoV‑2 and can quickly isolate and enrich both live and inactivated SARS-CoV-2 intact virus or virus-like particles (VLP). Quickly purify the virus from dilute samples and scale up to high-throughput using KingFisher automation instruments. Features of this kit include:

  • Rapid isolation of intact SARS-CoV-2 virus in ~20 minutes
  • Automation capable with KingFisher instruments
  • High throughput up to 96 samples per run
  • Intact virus samples that can be used in any functional assay
  • Release of the virus from the magnetic beads in ~10 minutes

MagMAX Viral/Pathogen Nucleic Acid Isolation Kits

Isolate RNA from viruses quickly and efficiently using the Applied Biosystems MagMAX Viral/Pathogen Nucleic Acid Isolation Kits with both manual and automated protocols. Features of this kit include:

  • Automation-ready protocols designed for Thermo Scientific KingFisher Flex and KingFisher Duo Prime systems
  • Manual-ready protocol and user guide for use with a magnetic stand
  • Fast procedure allows for 96 samples to be processed in <40 minutes
  • Flexible protocol accommodates sample volume inputs from 200 µL to 2 mL of blood, urine, swabs, lavage, and various transport media such as Universal Viral Transport medium, and Eswab preservative fluid
  • Compatible with bronchoaveolar lavage and other respiratory samples
  • Elution volumes ranging from 50 to 100 µL

Automated nucleic acid purification systems

For fast, easy, and effective high-throughput sample processing, automate your nucleic acid isolation with the KingFisher Flex system, a versatile benchtop instrument for the processing of 24 or 96 samples per run. Features of this system include:

  • High-throughput purification of 24–96 samples per run
  • Easy to install and run (ready to run in 10 minutes or less)
  • Choose from two plate formats for wide volume range (20–5,000 µL)
  • Download existing protocols from a library, or easily customize protocols using Thermo Scientific BindIt Software
  • See all purification systems

Spin column viral RNA/DNA purification

All of our viral spin-column kits including PureLink Viral RNA/DNA Mini Kit, Thermo Scientific GeneJET Viral DNA/RNA Purification Kit and PureLink Pro 96 Viral RNA/DNA Kit with 96-well plate are designed for fast and easy isolation of viral RNA or DNA from cell-free samples such as serum, plasma, cerebrospinal fluid, and cell culture supernatant.

  • Complete solution for both viral RNA and DNA
  • Yields highly concentrated viral nucleic acids for greater sensitivity in detection
  • Ideal for real-time PCR and endpoint analysis

Some viral kits are experiencing long lead times but there is another option. See our manual isolation solution using MagMAX Viral/Pathogen Nucleic Acid Isolation kits.

Purification essentials

The RNA purification process consists of a variety of unique challenges, one of which is ribonuclease contamination. Even a trace amount of RNase contamination can sabotage your experiments. Our essential RNA products act as a complete solution to help you avoid, detect, and inhibit RNases.

  • Surface RNase decontamination – The CDC recommends that prior to equipment preparation, researchers clean and decontaminate all work surfaces, pipettes, centrifuges, and other equipment using Thermo Fisher Scientific RNaseZap Surface Decontamination solution.
  • Nuclease-Free Water – Certified nuclease-free water products available in a wide range of sizes and packaging formats for your viral research.
  • Nuclease-Free Buffers & Reagents – RNA and DNA storage buffers, general-use buffers, and molecular biology-grade reagents, all rigorously tested and shown to be nuclease-free.
  • Nuclease-Free Tips and Tubes (Nuclease-free tubes and tips) – Certified nuclease-free (RNase- and DNase-free) tubes and tips designed for handling RNA and DNA with confidence.
  • RNA Stabilization – Stabilize and preserve the integrity of RNA either at the point of collection or even post-collection of your viral samples. Renders infectious samples non-infectious to keep you and your lab safe.

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