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TSQ Triple Quadrupole Mass Spectrometry (MS) Product Portfolio
LC/MS platform solutions designed to help you address your goals
From addressing complexities of molecules and matrices, to ensuring ease-of-use while satisfying regulatory requirements—today’s challenges in targeted quantitation involve more than just measuring concentrations of target analytes. Achieve ultimate confidence in your data quality with a robust, sensitive, reproducible, and reliable targeted quantitation method using our new liquid chromatography mass spectrometry (LC/MS) workflow solutions.
40 year anniversary of Thermo Scientific development and success of triple quadrupole mass spectrometers
For today and what's next
TSQ Altis Quadrupole Mass Spectrometer
Ultimate sensitivity & selectivity to meet tomorrow’s standards today
For everyday excellence
TSQ Quantis Quadrupole
Mass Spectrometer
Everyday quantitation workhorse to meet today’s standards
For a new level of confidence
TSQ Fortis Triple Quadrupole Mass Spectrometer
Quality data across workflows for users at all levels of expertise
Product comparison
| Triple Quad Product Comparison |  Access Max |  Fortis |  Endura |  Quantis |  Altis |
| Sensitivity | ++ | +++ | +++ | ++++ | +++++ |
| Resolution | ++ | ++ | ++ | ++ | +++ |
| Scan Speed | +++ | ++++ | +++ | ++++ | ++++ |
| Applications across multiple matrices | |||||
| Targeted quantitation in Proteomics | No | No | Yes | Yes | Yes |
| Peptide and protein quantitation (Biopharma) | No | No | Yes | Yes | Yes |
| Small molecule quantitation (Pharma, Clinical Research) | Yes | Yes | Yes | Yes | Yes |
| Small molecule mixture quantitation (Environmental Safety, Food Safety, Forensic Toxicology, Pharma) | Yes | Yes | Yes | Yes | Yes |
| Analysis and targeted quantitation of trace impurities (Impurity Quantitation) | Yes | Yes | Yes | Yes | Yes |
| Targeted quantitation in Omics (metabolomics, lipidomics) | No | Yes | Yes | Yes | Yes |
| Critical Features | |||||
| MRM for reliable identification | Yes | Yes | Yes | Yes | Yes |
| Multiple Source Compatibility | Yes | Yes | Yes | Yes | Yes |
| High Resolution SRM: for increased selectivity and sensitivity for analytes or multiple analytes in complex matrices | ++ | ++ | ++ | ++ | +++ |
| Segmented quadrupoles for increased ion efficiency | No | Yes | No | Yes | Yes |
| Neutral blocker for increased robustness | Yes | Yes | Yes | Yes | Yes |
| Increased dynodes in detector for increased lifetime and better linear dynamic range | No | Yes | No | Yes | Yes |
| APCI compatible with HESI source | No | Yes | No | Yes | Yes |
| Polarity Switching: Fast switching with stabilization enable faster quantitation assays for every molecule type | + | + | + | + | + |
| System Remote Monitoring | Yes | Yes | Yes | Yes | Yes |
| Assist with 21 CFR Part 11 Compliance (appropriate software) | No | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software |
| Instrument IQ/OQ assist | No | Yes | Yes | Yes | Yes |
| Thermo Fisher Cloud: Access, process, review data whenever you like, from wherever you are | No | No | Yes | Yes | Yes |
| Wi-Fi Connectivity: Access your data, Check your assay performance remotely | Yes | Yes | Yes | Yes | Yes |
| Size | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) |
| IVD Platform | No | No | Available in certain countries | No | No |
| Compatible separation technologies | UltiMate, Vanquish, Multiplexing, Capillary LC, Other vendors | UltiMate, Vanquish, Multiplexing, Capillary LC, Other vendors | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC |
| Compatible Software? | Xcalibur, TraceFinder | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon |
| Library availabilty | Yes | Yes | Yes | Yes | Yes |