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Improve Results in Forensics, Doping and Toxicology Analysis
No need to worry about your trace level analysis anymore – find the right tools to detect down to the last femtogram!
Trace analysis requires many different techniques to reach the required detection limits. It all starts with the right sample preparation and using the best quality vials to prevent the loss of analytes before they enter the LC-MS and/or GC-MS.
On this page, you will find useful information covering the workflow in the toxicology and forensic lab from sample to results.
View our educational materials and latest applications for:
- Sample preparation
- Liquid and Ion Chromatography
- Gas Chromatography
Connect with us to move your analysis to the next level!
We offer solutions and expertise.
Forensic and toxicology analysis continuously undergoes new requirements. But everything leaves a trace. Connect with an expert
In the spotlight: Fentanyl/norfentanyl analysis
Fast, accurate fentanyl analysis allows withdrawal clinics to perform timely tests, even if a small concentration of fentanyl was abused, and subsequently plan appropriate treatments for drug abuse patients. Here we present a workflow for the detection of fentanyl and norfentanyl after the abuse of fentanyl skin patches.
Improving analytical results often means focusing mainly on analytical instruments and method parameters. But do you ask yourself the important questions?
- Am I using the right material in my SPE for either LC-MS or GC-MS analysis?
- Am I using the best possible glass quality for my vials and GC liners?
- Do my samples require storage and/or filtration?
We are a global leader for chromatography consumables and offer you a wide portfolio of best in class vials and SPE cartridges, as well as syringes and syringe filters.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On Demand Webinars
- Fundamentals of Solid Phase Extraction for forensics and toxicology: Hear about the theory and concept of solid phase extraction, sample preparation options, step-by-step guide and toubleshooting.
- A workflow for the analysis of new psychoactive substances:
A complete workflow for NPS from sample preparation, through all relevant steps to detection wtih single quadrupole GC-MS is presented.
Request instant access ›
Video
- Workflow for the analysis of new psychoactive substances at LVR:
This video shows a complete workflow for the analysis of drugs of abuse including SPE and GC-MS.
Request instant access ›
eBook
- Clinical research and forensic handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions — to help facilitate your clinical research and forensic testing.
Request instant access ›
White Paper
- Why is high glass quality so important when you want to detect low concentrations of analytes?
Download
Forensic/toxicology analyses can be complex, and can require the use of multiple techniques to obtain accurate results. LC-MS is especially helpful when looking into polar analytes and structural changes in the world of drugs of abuse. To obtain the necessary tools and knowledge required for success in this challenging field, we offer webinars, online workflows and solutions, educational videos, and the opportunity to talk to one of our experts.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On-Demand Webinars
- Addressing Challenges with Confidence using LC-MS for Clinical Research: Discover widely used LC-MS based solutions that leverage high resolution accurate mass or triple quadrupole mass spectrometers enabling every single clinical research and toxicology laboratory.
Request instant access › - Use of LC-MS/MS for Testing of Nicotine in e-Cigarette Vapors | Broughton Nicotine Services:
Development and validation of a fast, routine analytical test method for quantitation of nicotine in ENDS vapours
Request instant access › - High Resolution Orbitrap MS for Detecting New Psychoactive Drugs: A User’s Perspective
- Advances in Forensic Analysis - When to Use HRAM/HRMS
- An Intelligence-Led Approach to the Detection of Drugs of Abuse and Novel Psychoactive Substances
Videos
- Reducing Caseload in Forensic Laboratories (6 minutes)
- Orbitrap Mass Spectrometry-New Tools to Combat the Growing Opioid Epidemic
Technical Notes
Forensic Toxicology Learning Center
- Whether you screen and confirm known compounds, identify unknowns or advance forensic research, we have a solution to meet your current and future needs.
Access library/Learning Center ›
eBooks
- Removing Doubt in Forensic Science – Mass Spectrometry Workflows Solving Forensic Cases:
Overview of the current state of forensic chemistry and the latest mass spectrometry technology for staying ahead of your casework
Request instant access › - Identify Rapidly Evolving Novel Psychoactive Drug Substances Faster;
Discover the growing list of NPS, identifying and prohibiting NPS faster, reducing human and societal cost, determining drug circulation networks more rapidly, and staying ahead of emerging trends.
Request instant access › - Tomorrow’s Quantitation Interactive:
Whether you perform your quantitation analyses by triple quadrupole mass spectrometry or using the high resolution accrate mass (HRAM) capabilities of an Orbitrap system, this compendium gives examples of how to develop robust assays across a variety of different sample types.
Request instant access › - Clinical Research and Forensic Handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions
Request instant access › - Drugs of Abuse: Reliable Analysis through Orbitrap Mass Spectrometry
View now › - Promises and Pitfalls of Alternative Matrices: Capture the Drug Traces You Need
View now ›
Forensic/toxicology is a challenging field, and many analyses that are required are not considered routine. Samples and analytes are subject to change on a daily basis, but GC-MS technology is still the “gold standard” for many unknown analyses. For some analysis, a GC single quadrupole with deconvolution software is ideal. However, there are also more advanced cases which require additional capabilities.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On-Demand Webinars
- Orbitrap GC-MS - Unknowns discovery workflows for the characterization of e-cigarette liquids: Hear about high resolution accurate mass coupled with GC as a powerful tool to innovate routine analysis. It provides a simple set-up using full scan, non-targeted acquisition that allows target compounds to be decired post acquisition
- A workflow for the analysis of new psychoactive substances: A complete workflow for NPS from sample preparation, through all relevant steps to detection wtih single quadrupole GC-MS is presented.
Request instant access › - Overcoming challenges in sport doping analysis:
Hear about 428 prohibited substances detected in urine by UHPLC Orbitrap LC-MS and the identification of exogenous steroids in urine by GC-IRMS.
Request instant access ›
- Advances in forensic analysis: When to use GC-MS & GC-MS/MS (23 minutes)
- Advances in forensic analysis. When to Use HRAM/HRMS (22 minutes)
- Reducing caseload in forensic laboratories (6 minutes)
- Effective sample preparation for sensitive analysis of drugs of abuse with GC-MS for clinical research and forensic toxicology (Language: German; 10 minutes)
- Advances in forensic analyses. When to use GC-MS & GC-MS/MS
Videos
- Advances in forensic analyses. When to use GC-MS & GC-MS/MS (23 minutes)
- When to Use HRAM/HRMS (22 minutes)
- Reducing caseload in forensic laboratories (6& minutes)
- Effective sample preparation for sensitive analysis of drugs of abuse with GC-MS for clinical research and forensic toxicology (Language: German; 10 minutes)
Ebook
- Clinical research and forensic handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions
Request instant access ›
Blogs
- Sports doping – How isotopes help to fight the crime
Read more › - Sensitive screening for drugs of abuse in urine by SPE and GC-MS
Read more › - Sensitive Quantitation of THCCOOH in Hair by GC-MS/MS
Read more ›
Technical Notes
From blood alcohol, to drugs of abuse or sports doping analysis – Learn about our innovative forensic applications for your lab. We provide standard solutions to out of the box analytical concepts.
One of the major challenges in the analysis of drugs of abuse is to determine the country and source of origin.
By studying the isotope fingerprints, carbon, nitrogen, hydrogen, oxygen and sulfur, the isotope hunters among other forensic investigations, can reveal the real origin and real geographical cultivation areas of drug of abuse.
Applying isotope fingerprints to forensic questions allows investigators to provide a unique characterization of the sample material and so trace reactants, chemical pathways and reaction conditions, relative to natural processes. From this basis, using isotope fingerprints makes it possible to determine similarities between different drug seizures and authentic material and to follow trafficking routes to their original source.
Resources
Webinar
Panel discussion on Isotope Fingerprints: The common thread between forensic applications: from food and beverage adulteration to crime scenes investigations
View now ›
Video
Whiteboard video on Isotope Fingerprints for forensic applications (including origin of drugs)
View now ›
Blog post
How Isotope Hunters Are Using Isotope Fingerprints to Solve Criminal Forensic Cases
Read more ›
Technical notes
Infographic
Immunoassay screening with Thermo Scientific DRI Fentanyl Assay.
The DRI Fentanyl Assay is supplied as liquid ready-to-use homogeneous enzyme
immunoassay. The assay uses fentanyl specific monoclonal antibody that can detect fentanyl
without any significant cross-reactivity to other opiate compounds.
Improving analytical results often means focusing mainly on analytical instruments and method parameters. But do you ask yourself the important questions?
- Am I using the right material in my SPE for either LC-MS or GC-MS analysis?
- Am I using the best possible glass quality for my vials and GC liners?
- Do my samples require storage and/or filtration?
We are a global leader for chromatography consumables and offer you a wide portfolio of best in class vials and SPE cartridges, as well as syringes and syringe filters.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On Demand Webinars
- Fundamentals of Solid Phase Extraction for forensics and toxicology: Hear about the theory and concept of solid phase extraction, sample preparation options, step-by-step guide and toubleshooting.
- A workflow for the analysis of new psychoactive substances:
A complete workflow for NPS from sample preparation, through all relevant steps to detection wtih single quadrupole GC-MS is presented.
Request instant access ›
Video
- Workflow for the analysis of new psychoactive substances at LVR:
This video shows a complete workflow for the analysis of drugs of abuse including SPE and GC-MS.
Request instant access ›
eBook
- Clinical research and forensic handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions — to help facilitate your clinical research and forensic testing.
Request instant access ›
White Paper
- Why is high glass quality so important when you want to detect low concentrations of analytes?
Download
Forensic/toxicology analyses can be complex, and can require the use of multiple techniques to obtain accurate results. LC-MS is especially helpful when looking into polar analytes and structural changes in the world of drugs of abuse. To obtain the necessary tools and knowledge required for success in this challenging field, we offer webinars, online workflows and solutions, educational videos, and the opportunity to talk to one of our experts.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On-Demand Webinars
- Addressing Challenges with Confidence using LC-MS for Clinical Research: Discover widely used LC-MS based solutions that leverage high resolution accurate mass or triple quadrupole mass spectrometers enabling every single clinical research and toxicology laboratory.
Request instant access › - Use of LC-MS/MS for Testing of Nicotine in e-Cigarette Vapors | Broughton Nicotine Services:
Development and validation of a fast, routine analytical test method for quantitation of nicotine in ENDS vapours
Request instant access › - High Resolution Orbitrap MS for Detecting New Psychoactive Drugs: A User’s Perspective
- Advances in Forensic Analysis - When to Use HRAM/HRMS
- An Intelligence-Led Approach to the Detection of Drugs of Abuse and Novel Psychoactive Substances
Videos
- Reducing Caseload in Forensic Laboratories (6 minutes)
- Orbitrap Mass Spectrometry-New Tools to Combat the Growing Opioid Epidemic
Technical Notes
Forensic Toxicology Learning Center
- Whether you screen and confirm known compounds, identify unknowns or advance forensic research, we have a solution to meet your current and future needs.
Access library/Learning Center ›
eBooks
- Removing Doubt in Forensic Science – Mass Spectrometry Workflows Solving Forensic Cases:
Overview of the current state of forensic chemistry and the latest mass spectrometry technology for staying ahead of your casework
Request instant access › - Identify Rapidly Evolving Novel Psychoactive Drug Substances Faster;
Discover the growing list of NPS, identifying and prohibiting NPS faster, reducing human and societal cost, determining drug circulation networks more rapidly, and staying ahead of emerging trends.
Request instant access › - Tomorrow’s Quantitation Interactive:
Whether you perform your quantitation analyses by triple quadrupole mass spectrometry or using the high resolution accrate mass (HRAM) capabilities of an Orbitrap system, this compendium gives examples of how to develop robust assays across a variety of different sample types.
Request instant access › - Clinical Research and Forensic Handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions
Request instant access › - Drugs of Abuse: Reliable Analysis through Orbitrap Mass Spectrometry
View now › - Promises and Pitfalls of Alternative Matrices: Capture the Drug Traces You Need
View now ›
Forensic/toxicology is a challenging field, and many analyses that are required are not considered routine. Samples and analytes are subject to change on a daily basis, but GC-MS technology is still the “gold standard” for many unknown analyses. For some analysis, a GC single quadrupole with deconvolution software is ideal. However, there are also more advanced cases which require additional capabilities.
Resources
Use our useful tools for the knowledge that is required for success in this challenging field.
On-Demand Webinars
- Orbitrap GC-MS - Unknowns discovery workflows for the characterization of e-cigarette liquids: Hear about high resolution accurate mass coupled with GC as a powerful tool to innovate routine analysis. It provides a simple set-up using full scan, non-targeted acquisition that allows target compounds to be decired post acquisition
- A workflow for the analysis of new psychoactive substances: A complete workflow for NPS from sample preparation, through all relevant steps to detection wtih single quadrupole GC-MS is presented.
Request instant access › - Overcoming challenges in sport doping analysis:
Hear about 428 prohibited substances detected in urine by UHPLC Orbitrap LC-MS and the identification of exogenous steroids in urine by GC-IRMS.
Request instant access ›
- Advances in forensic analysis: When to use GC-MS & GC-MS/MS (23 minutes)
- Advances in forensic analysis. When to Use HRAM/HRMS (22 minutes)
- Reducing caseload in forensic laboratories (6 minutes)
- Effective sample preparation for sensitive analysis of drugs of abuse with GC-MS for clinical research and forensic toxicology (Language: German; 10 minutes)
- Advances in forensic analyses. When to use GC-MS & GC-MS/MS
Videos
- Advances in forensic analyses. When to use GC-MS & GC-MS/MS (23 minutes)
- When to Use HRAM/HRMS (22 minutes)
- Reducing caseload in forensic laboratories (6& minutes)
- Effective sample preparation for sensitive analysis of drugs of abuse with GC-MS for clinical research and forensic toxicology (Language: German; 10 minutes)
Ebook
- Clinical research and forensic handbook:
Free 880 pages handbook with technical notes, educational tools, peer reviewed references and new information about our innovative sample preparation, chromatography and MS solutions
Request instant access ›
Blogs
- Sports doping – How isotopes help to fight the crime
Read more › - Sensitive screening for drugs of abuse in urine by SPE and GC-MS
Read more › - Sensitive Quantitation of THCCOOH in Hair by GC-MS/MS
Read more ›
Technical Notes
From blood alcohol, to drugs of abuse or sports doping analysis – Learn about our innovative forensic applications for your lab. We provide standard solutions to out of the box analytical concepts.
One of the major challenges in the analysis of drugs of abuse is to determine the country and source of origin.
By studying the isotope fingerprints, carbon, nitrogen, hydrogen, oxygen and sulfur, the isotope hunters among other forensic investigations, can reveal the real origin and real geographical cultivation areas of drug of abuse.
Applying isotope fingerprints to forensic questions allows investigators to provide a unique characterization of the sample material and so trace reactants, chemical pathways and reaction conditions, relative to natural processes. From this basis, using isotope fingerprints makes it possible to determine similarities between different drug seizures and authentic material and to follow trafficking routes to their original source.
Resources
Webinar
Panel discussion on Isotope Fingerprints: The common thread between forensic applications: from food and beverage adulteration to crime scenes investigations
View now ›
Video
Whiteboard video on Isotope Fingerprints for forensic applications (including origin of drugs)
View now ›
Blog post
How Isotope Hunters Are Using Isotope Fingerprints to Solve Criminal Forensic Cases
Read more ›
Technical notes
Infographic
Immunoassay screening with Thermo Scientific DRI Fentanyl Assay.
The DRI Fentanyl Assay is supplied as liquid ready-to-use homogeneous enzyme
immunoassay. The assay uses fentanyl specific monoclonal antibody that can detect fentanyl
without any significant cross-reactivity to other opiate compounds.