Achieve Tomorrow’s Quantitation with LC-MS Today

Tomorrow's quantitation provides certainty for complex analysis

Analytical demands are making quantitation more than just quantifying targeted analytes. Traditional quantitation was fueled by the knowledge of what compounds and/or contaminants were present in each sample. Scientists knew what they were testing and were able to rely on proven and well-tested technologies to quantify the target analytes. Today’s quantitation requires both qualitative and quantitative assessment. Screen, identify, and quantify more analytes than ever before with our LC/MS systems, which are ready for today's and tomorrow's quantitation needs. Because tomorrow's quantitation provides certainty for complex analysis today.

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According to SDI’s Global Assessment 2018 report, quadrupole LCMS made up over one third of total mass spectrometry sales due to its wide usage in life science applications spanning pharmaceuticals, biotechnology, clinical research labs and academic research. However, the report expects to see fast growth in quantitative high-resolution mass spectrometry, such as quantitative Orbitrap and QTOF LCMS, as the demand for screening and quantitation of unknown compounds of interest continues to climb.

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Find out which LCMS system might be right for you

The landscape for analytical laboratories is evolving; quantitation is not as straight forward as it was in the past.  While triple quadrupole LCMS continues to be popular in industries associated with validated targeted quantitative methods, the pharmaceutical and biopharmaceutical laboratories are increasingly using quantitative high resolution accurate mass (HRAM) Orbitrap-based techniques to characterize their complex samples.  Equally, over the next five years the applied segments (including food, clinical research, forensic toxicology and environmental testing) are expected to grow faster as concerns continue to arise to test for emerging compounds and contaminants; in a more efficient manner.

Advantages of HRAM and QqQ LC/MS technologies

The ability to develop robust and reliable assays with both triple quadrupole (QqQ) and high resolution accurate mass (HRAM) LC/MS systems has made these technologies a common choice when it comes to quantitation of analytes in complex matrices. Both QqQ and HRAM technologies offer unique advantages, enabling supreme confidence in the quantitation of a variety of molecule types.

Untargeted screening
Targeted screening
Untargeted and targeted quantitation
Targeted quantitation only
Retrospective analysis
= Not applicable = Poor = Good = Better = Best

Which HRAM is right for you?  Which QQQ is right for you?  Which HPLC is right for you?  Which IC is right for you?

How to select the most efficient approach for data acquisition and analysis

Taking qualitative discovery data from high-resolution systems, through to quantitation was traditionally a labour-intensive and manual process. Now, advancing screening through to quantitation is more streamlined and seamless than ever before. Data from studies using high-resolution MS systems can be easily interpreted with Thermo Scientific Compound Discoverer software, through the use of powerful data analysis tools and access to the World’s largest mass spectral fragmentation library mzCloud.

Once you’ve acquired the necessary insights and knowledge from your data, this can in-turn be easily transferred to generate routine quantitative and targeted screening workflows using either high-resolution or QqQ MS.

Which data analysis software is right for you?

NeedsCompound DiscovererTraceFinderChromeleon CDS
Untargeted, unknown screening (unknown knowns and unknown unknowns)
Targeted screening (known unknowns)
Untargeted and targeted quantitation
Targeted quantitation only (known knowns)
Complex targeted panel analysis
GxP/21 CFR Part 11 compliance capable
Library compatibility
Thermo Scientific Chromatography and source compatibility
Third Party Instrument Control
= Not applicable = Poor = Good = Better = Best

Customer and application spotlights

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