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UNSTOPPABLE GC-MS and GC-MS/MS Analysis
Introducing the UNSTOPPABLEThermo Scientific ISQ 7000 single quadrupole GC-MS and TSQ 9000 triple quadrupole GC-MS/MS systems. These truly scalable platforms power your inner superhero with UNSTOPPABLE sensitivity, uptime, and ease of use. Now you can revolutionize your analyses for a range of sample types, all while increasing throughput and reducing cost-per-sample.
- Ultimate sensitivity with Advanced Electron Ionization source
- Routine ease-of- use from method development to daily operation
- Extended uptime with inherent robustness and NeverVent™ technology
- True scalability to face evolving regulatory requirements
UNSTOPPABLE GC-MS analysis
Laboratories performing food, environmental, or forensic toxicology testing demand analytical systems that are unstoppable in every way. That’s the inspiration behind the Thermo Scientific ISQ 7000 single quadrupole GC-MS system. With UNSTOPPABLE sensitivity, ease of use and uptime, this truly scalable platform empowers you to become a real-life superhero. Now you can prevail over increasingly challenging regulatory requirements and productivity pressure.
UNSTOPPABLE sensitivity
Click image to enlarge
The ISQ 7000 GC-MS system delivers highest sensitivity, being able to reach detection limits as low as sub-femtogram-levels. Whether you run in selected ion monitoring (SIM) or full scan modes, you consistently achieve the required response as you analyze samples. Achieving low detection limits requires breaking noise-reduction boundaries. The ISQ 7000 GC-MS system does so with pre-filters having a unique ion path that neutrals cannot navigate.
Choose either the rugged Thermo Scientific ExtractaBrite ion source technology or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) source. Available in a dedicated system configuration, the AEI source allows you to drive down instrument detection limits and reduce time-consuming sample concentration steps.
UNSTOPPABLE uptime
Extended instrument uptime reduces turnaround time and overhead costs. Robust design ensures that your ISQ 7000 GC-MS system continues to produce the highest-quality results possible. Whether you select the ExtractaBrite or AEI ion source, you benefit from high matrix tolerance to minimize routine maintenance.
With NeverVent technology for the ExtractaBrite source, it’s possible to isolate the mass spectrometer from the gas chromatograph, allowing source cleaning, column replacement, or injector maintenance, without downtime for venting. This makes the ISQ 7000 a useful tool for eliminating waste and maximizing laboratory efficiency.
UNSTOPPABLE ease of use
The ISQ 7000 GC-MS system improves user experience with automated software tools to streamline instrument tuning, method development, targeted quantification, and untargeted screening workflows. The software also makes it easy to transition to the ISQ 7000 GC-MS system from other platforms by facilitating instrument familiarization.
AutoSIM and Timed-SIM (t-SIM) automate method development and optimization for targeted SIM workflows. Retention Time Alignment (RTA) allows you to set analyte retention times, and facilitate high-throughput work. Untargeted screening methods are likewise simplified. Mass spectral deconvolution unravels heavy co-elution by reconstructing clean mass spectra that are ready for library searching, identification, and confirmation. For any workflow, SmartTune simplifies tuning procedures and, if required, notifies the user of any necessary corrective actions.
Target analysis
Method development
Routine analysis
AutoSIM
AutoSIM allows you to acquire full-scan data, enter or import from external file (csv, Excel, LIMS database) your list of target analytes, and perform selection of the SIM ions from the FS data in a guided, automated fashion. A real time saver and productivity booster.
Timed-SIM method
Timed Acquisition (t-SIM) helps optimize the dwell times in SIM quantitation methods with large number of analytes, especially in case of co-elution, assuring the maximum sensitivity. However, a manual set up of t-SIM can be tedious. This is why AutoSIM is complementary to t-SIM, for a fully automated workflow.
Retention Time Alignment (RTA)
The new RTA tool uses Void Time and Retention Time of a reference substance to provide new carrier flow and pressure settings or new columns dimension settings to realign retention times of all the peaks of the chromatograms. This means that during a column change or trim, you can quickly re-align the retention times and return to collecting results.
Untargeted screening
Method development
Routine analysis
Full-scan acquisition
For untargeted analysis, leverage the easier and quick set up of a full-scan acquisition method, maintaining the analytical information of the entire mass range.
Mass spectral deconvolution
Unravel the heaviest co-elution of the TIC chromatogram by reconstructing clean mass spectra for heavy co-eluted compounds, ready for reliable library searching and ID confirmation.
Mass spectral deconvolution (continued)
SmartTune
SmartTune is the new simplified tuning tool for Thermo Scientific ISQ and TSQ instruments. This intuitive tool removes tuning complexity and ensures your system is performing at the level you require, ahead of running your samples. A simple guided interface efficiently checks and tunes the system, and intelligently eliminates any unnecessary steps in the process, resulting in faster tuning operations. If a problem is detected, SmartTune advises you on recommended corrective action. In addition, SmartTune allows user customizable targets to facilitate consistency in performance between analytical sequences.
UNSTOPPABLE scalability
Click image to enlarge
In an evolving world, it’s important to be prepared for the future. The fully scalable ISQ 7000 GC-MS system provides a upgrade path from basic to advanced configurations, allowing you to add capability if you need it. With five performance and price levels, and field-upgrade options, you can invest in fit-for-purpose solutions at the right cost and still expand your analytical capability in the future.
UNSTOPPABLE workflows
Pressure to increase productivity, and the growing list of compounds that laboratories must quantify and screen, necessitate workflow-driven software. Intuitive Thermo Scientific Chromeleon Chromatography Data System (CDS) software is available to streamline quantitative workflows. Download ready-to-use Thermo Scientific eWorkflows from the Thermo Scientific AppsLab Library to jump-start method development. For U.S. EPA-based environmental applications, the Environmental Analysis Extension Pack provides a set of GC-MS e-workflow and reporting templates.
- Fixed Calibration, Check Standards, QC Samples, Unknowns
- Tune Check, Calibration Curve, QC Samples
- Fixed Calibration, Check Standards, Injections for computing Minimum Detection Level (MDL)
- Fixed Calibration, Check Standards, Injections for performing method validation
UNSTOPPABLE GC-MS/MS analysis
Laboratories performing food, environmental, forensic toxicology and other routine testing demand analytical systems that are unstoppable in every way. That’s the purpose of the Thermo Scientific TSQ 9000 triple quadrupole GC-MS/MS system. This truly scalable platform delivers unprecedented sensitivity for targeted quantitation of trace and ultra trace-level compounds in complex sample matrices. Add unrivaled ease of use and uptime, and you become a real-life superhero empowered to prevail over increasingly challenging regulatory requirements and productivity pressure.
UNSTOPPABLE sensitivity
Click image to enlarge
The TSQ 9000 GC-MS/MS system is able to deliver sensitivity into the attogram range and best-in-class selected-reaction-monitoring (SRM) performance, so you consistently meet required detection limits for high capacity methods as you test samples.
Choose either the rugged Thermo Scientific ExtractaBrite ion source or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) source. Available in a dedicated system configuration, the AEI source provides highly efficient ionization and a more tightly focused ion beam to drive down instrument detection limits and reduce time-consuming sample concentration steps.
The Enhanced Velocity Optics Collision Cell (EvoCell) augments sensitivity and precision for complex methods. It can be used to increase the scope of SRM methods to fit a wider range of compounds and matrices, increase sample throughput by compressing GC time, or increase method resistance to matrix effects and retention time shifts.
UNSTOPPABLE uptime
Click image to enlarge
Extended instrument uptime reduces turnaround time. The TSQ 9000 GC-MS/MS system is designed specifically for complex sample matrices in high-throughput applications. Whether you select the ExtractaBrite or AEI ion source, you benefit from high matrix tolerance to minimize maintenance intervals.
NeverVent technology takes GC-MS/MS uptime to a new level. The vacuum probe interlock (VPI) with the ExtractaBrite source and V-Lock source plug, make it possible to isolate the vacuum system on the mass spectrometer, allowing source cleaning, and ion source and column changing, without downtime for venting. Now you can eliminate up to 98% of the downtime associated with routine GC-MS system maintenance.
UNSTOPABBLE ease of use
The TSQ 9000 GC-MS/MS system enhances user experience, learning, and ease of switching from other platforms with automated software for method development, routine operation, and targeted quantification workflows.
SIM Bridge, AutoSRM, and t-SRM automate development and optimization of SRM-based targeted workflows, allowing even less-experienced users to develop powerful MS/MS-based methods. Retention Time Alignment (RTA) adds an easy way to maintain retention times for high-throughput work. SmartTune simplifies instrument tuning and, if needed, informs the user of corrective actions, ensuring the system performs as required.
Method development
SIM Bridge
- The SIM Bridge tool allows SIM methods exported from other sources to be translated to the TSQ 9000 system method. Those SIM methods can be immediately run on the TSQ 9000 system or through AutoSRM to translate the SIM information into a powerful SRM method.
AutoSRM
- AutoSRM is your very own mass spectrometer method development expert integrated into your system. This software walks you through the development of fully optimized SIM target ions or SRM transitions in a very simple and efficient workflow. If you like to develop from your current SIM method, SIM Bridge streamlines the workflow by importing your method details. All together, it is full MS and MS/MS method development independence, even for the less experienced user.
Timed-SRM method
- As more compounds are added to a single run, managing acquisition windows becomes increasingly complex. The TSQ 9000 system dramatically reduces this complexity by automatically optimizing the targeting of a particular compound. Simply enter the retention time and the time required to capture the peak, and t-SRM takes care of the rest. This ensures that compound detection is optimized for maximum sensitivity, and more compounds can be added to the method without compromising the excellent sensitivity of each individual analyte. The mass spectrometer is not consuming valuable resources scanning for compounds at the times when those compounds are not eluting.
Routine analysis
Retention Time Alignment (RTA)
- The new RTA tool is a faster, more flexible and easier way to maintain retention times during routine operation of high-throughput GC-MS methods. The tool uses the measured void time of the column and the retention time of a reference substance to provide a new column length and internal diameter settings (or corrected pressure or flow value) to realign retention times of all the peaks of the chromatograms. This means that during a column change or trim, the user can quickly re-align their retention times and return to collecting results.
SmartTune
- SmartTune is the new simplified tuning tool for Thermo Scientific ISQ and TSQ instruments. This intuitive tool removes tuning complexity and ensures your system is performing at the level you require, ahead of running your samples. A simple guided interface efficiently checks and tunes the system, and intelligently eliminates any unnecessary steps in the process, resulting in faster tuning operations. If a problem is detected, SmartTune advises you on recommended corrective action. In addition, SmartTune allows user customizable targets to facilitate consistency in performance between analytical sequences.
UNSTOPPABLE scalability
Click image to enlarge
It’s difficult to predict the analytical challenges that lie ahead. The fully scalable TSQ 9000 GC-MS/MS system provides an upgrade path that enables basic to advanced configurations, allowing you to add capability when you need it.
UNSTOPPABLE workflows
Pressure to increase productivity, and the growing list of compounds that laboratories must quantify and screen, necessitate workflow-driven software.
Intuitive Thermo Scientific Chromeleon Chromatography Data System (CDS) software is available to support quantitative workflows, and Thermo Scientific eWorkflows can be added to simplify creation of analytical workflows. If you need to jump-start method development, download ready-to-use eWorkflows from the Thermo Scientific AppsLab Library.
- Fixed Calibration, Check Standards, QC Samples, Unknowns
- Tune Check, Calibration Curve, QC Samples
- Fixed Calibration, Check Standards, Injections for computing Minimum Detection Level (MDL)
- Fixed Calibration, Check Standards, Injections for performing method validation
Innovative MS technology future-proofs GC-MS investment
Innovative technologies applied to the Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems work together to deliver UNSTOPPABLE GC-MS system performance. You get best-in-class sensitivity, uptime, and ease of use, future-proofing your investment to address increasingly challenging regulatory requirements.
ExtractaBrite ion source
Part of Thermo Scientific NeverVent technology, the Thermo Scientific ExtractaBrite ion source technology delivers proven rugged electron impact (EI) and chemical ionization (CI) performance. The source is removable for maintenance or switching ionization modes without breaking vacuum. In addition, by exchanging the ion source with the V-Lock source plug, GC columns can be replaced without venting.
To protect analyte integrity and maximum robustness, the ExtractaBrite ion source is comprised of highly inert material. It is also heated throughout to prevent mass analyzer contamination and to ensure matrix tolerance for high-throughput work. As a result, there is never a need to heat or clean the quadrupoles.
Advanced Electron Ionization (AEI) source
Click image to enlarge
The ultra-robust, ultra-sensitive Advanced Electron Ionization (AEI) source is available in dedicated ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS system configurations. Highly efficient ionization, a tightly focused ion beam, and heating throughout the source reduce mass spectrometer contamination, extend system uptime, and lower instrument detection limits to unprecedented levels. With ultra-high sensitivity, the AEI source can also help reduce sample concentration steps and consequent matrix pressure on the analytical system.
EvoCell
Click image to enlarge
Part of the TSQ 9000 triple quadrupole GC-MS/MS system, Enhanced Velocity Optics Collision Cell (EvoCell) technology boosts sample throughput with very high selected-reaction-monitoring (SRM) transition speeds, providing enhanced precision and sensitivity for even the most complex methods. Timed-SRM (t-SRM) software automates optimization of SRM scheduling.
EvoCell technology can be used to increase the scope of SRM methods to fit a wider range of compounds and matrices, increase sample throughput by compressing GC time, or increase method resistance to interferences, matrix effects, and retention time shifts.
NeverVent technology
Patented Thermo Scientific NeverVent technology delivers UNSTOPPABLE GC-MS uptime. Used with the ExtractaBrite ion source, the vacuum probe interlock (VPI) and the V-Lock source plug isolate the vacuum region of the mass spectrometer from the gas chromatograph, allowing routine source cleaning, and ion source and column changing, without venting.
Dual filament
Click to enlarge
The dual filament design extends instrument uptime. Both filaments produce similar analytical performance so you can switch from one to the other without impacting analytical performance. To simplify operation, the dual filament assembly is used for both EI and CI modes.
GC-MS transferline
Independently heated zones for transfer line, ion source, and ion optics help ensure that the system stays cleaner for a longer period of time.
The optimized GC-MS transferline evenly distributes heat across the length of the analytical column, ensuring that there are no hot or cold spots, which in turn delivers Gaussian peak shapes, even for high boiling point compounds.
Ion source probes
Optional ion source probes enable you to perform real-time MS and MS/MS experiments on solid samples with easy switching between EI and CI modes. Like the ExtractaBrite ion source, the probes can be removed without venting.
Available ion source probes:
Direct Insertion Probe (DIP) for rapid analysis of components in solid matrices.
Direct Exposure Probe (DEP) for rapid molecular weight confirmation of solids dissolved or suspended in liquid solvents.
MS software innovations advance method development
The Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems include a comprehensive set of software features for instrument tuning, and method development and optimization of targeted quantification and untargeted screening workflows. The software provides users with a seamless experience during the transition from other platforms.
AutoSIM and Timed-SIM
AutoSIM saves time during method set up. The software provides automated, user-selectable, criteria-guided development of SIM method from full scan data, either automatically acquired by AutoSIM or imported from external data files (CSV, Excel, LIMS database).
For maximum sensitivity, Timed-SIM (t-SIM) acquisition helps users optimize the dwell times used in SIM-based quantitation of large numbers of analytes, especially for co-eluting analytes. AutoSIM can be used together with t-SIM to completely automate workflows.
SIM Bridge and AutoSRM
SIM Bridge translates SIM methods from other sources into TSQ 9000 GC-MS/MS system methods. The SIM methods can then be immediately used as-is, or converted into more powerful SRM methods using AutoSRM.
AutoSRM walks users through selection of optimum SRM transitions for TSQ 9000 GC-MS/MS system methods. Together, SIM Bridge and AutoSRM enable even less-experienced staff to rapidly develop MS and MS/MS methods.
Timed-SRM
Click image to enlarge
As compounds are added to a method, managing acquisition-time windows becomes increasingly complex. For the TSQ 9000 GC-MS/MS system, t-SRM dramatically reduces this complexity by automatically optimizing the SRM parameters needed to attain sensitive detection and quantification. The user simply enters the retention time window for the target peak, and t-SRM takes care of the rest.
Retention time alignment
Click image to enlarge
Retention Time Alignment (RTA) is a fast, flexible, and easy way to maintain retention times during high-throughput GC-MS system operation. RTA uses the void time of the column and retention time of a reference substance to provide new column dimension settings, or to correct carrier gas pressure or flow values to realign chromatographic peaks. After a column replacement or trim, the user can quickly realign the retention time.
SmartTune
Click image to enlarge
SmartTune simplifies and speeds GC-MS instrument tuning and, if needed, recommends corrective actions. This helps ensure that your system performs at the levels you require for longer periods of time.
Step into GC 2.0
Boost productivity, accelerate response times, and lower your total cost of ownership with the Thermo Scientific TRACE 1310 Gas Chromatograph. Providing versatility and exceptional GC and GC-MS performance, it is an ideal choice for the Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems. Tailor the TRACE 1300 Series Gas Chromatograph to your needs with its proprietary user-exchangeable Instant Connect injector and detector modules, and a range of Thermo Scientific autosamplers, columns, and consumables.
Instant connect injectors and detectors
Swapping Instant Connect modules is easy: Simply remove and replace three screws, which are accessible from the top of the GC system. The entire process takes under five minutes without requiring specialized service assistance. Interchangeable modularity provides maximum uptime by allowing offline cleaning and servicing of the modules.
- The Instant Connect SSL (Split/Splitless) injector features an optimized thermal profile specially developed to avoid sample discrimination in split and splitless mode, allowing the broadest range of analytes to be accurately injected.
- The Instant Connect PTV (Programmed Temperature Vaporizing) injector combines the "discrimination-free" performance of a cold injector with the robustness of a vaporizing injector. This injector is ideal for trace analysis in difficult matrices and thermally labile compounds.
- The Instant Connect Helium Saver Module is a proprietary split/splitless injector that greatly reduces helium consumption. Helium supplies the carrier gas flow to the capillary column, while nitrogen is used for all other injection processes, including septum purge, split, and sample vaporization.
- The Instant Connect-FID (Flame Ionization Detector) offers highest sensitivity and a wide dynamic range with rapid acquisition speed, making it ideal for extremely fast GC applications.
- The micro-volume Instant Connect-TCD (Thermal Conductivity Detector) is non-destructive and provides exceptional thermal stability, fast response, and exceptional sensitivity over the widest range of applications.
- The Instant Connect-ECD (Electron Capture Detector) is optimized for selective trace analysis of organohalogenated compounds, even in challenging sample matrices. Its miniaturized cell, equipped with a purged, removable anode, is designed to guarantee the utmost sensitivity while maximizing robustness.
- The Instant Connect-NPD (Nitrogen Phosphorous Detector) brings exceptional sensitivity and selectivity for the determination of nitrogen or phosphorous-containing organic compounds.
- The Instant Connect-FPD (Flame Photometric Detector) provides excellent sensitivity and response stability for demanding sulphur applications, as well as phosphorous or tin determinations.
Choice of autosamplers
To meet your automation needs, choose the Thermo Scientific AI/AS 1310 Series, TriPlus RSH, TriPlus 100 LS and TriPlus 300 HS autosamplers.
- The AI/AS 1310 Series Autosampler improves the consistency and quality of GC results. Engineered to stand up to the demands of any busy high-throughput lab, this autosampler helps you process more samples quickly and cost-effectively.
- A step ahead in automated sampling, TriPlus RSH Autosampler uses robotic sample handling to expand automation beyond liquid, static, and dynamic headspaces, as well as solid-phase micro extraction (SPME) injections. This system also enables automation of basic sample and standards preparation procedures such as dilution, internal standard addition, and derivatization. Improved precision and reproducibility, even for low injection volumes, produce higher quality results.
- The Triplus 100 LS Autosampler is a robotic platform ideal for high sample throughput when only liquid injection is required. Fully compatible with Triplus RSH liquid accessories, it features a vial capacity that is upgradable from 162 up to 624 vials, nano- to large-volume injection capabilities, and flexible injection modes.
- Automate and accelerate your analyses of organic volatiles. The TriPlus 500 GC Headspace Autosampler helps increase sample turnaround and lower overall cost per analysis. Based on Valve-and-Loop technology, this autosampler also ensures the highest data quality and full compliance with regulatory statutes.
High-performance Thermo Scientific chromatography columns and consumables
Get the most out of your GC-MS system by pairing it with advanced, high-performance Thermo Scientific columns and consumables. Our wide range of consumables and accessories offer customers applications-focused solutions in the environmental, food safety, toxicology, clinical, petrochemical, pharmaceutical, and general analytical industries.
- Thermo Scientific TraceGOLD Columns—low bleed, high reproducibility
- Consumables tested and certified with TRACE 1300 Series GC systems
- Vials guaranteed for Thermo Scientific Autosampler systems
- Thermo Scientific GFM Pro Gas Flowmeter and Thermo Scientific GOLD Pro Gas Leak Detector for system installation and maintenance
- Derivatization reagents and derivatization-grade solvents
UNSTOPPABLE workflows
Streamlined, workflow-driven software solutions such as Thermo Scientific Chromeleon Chromatography Data System (CDS) and TraceFinder software empowers your lab to successfully address productivity needs and increasingly complex regulatory requirements.
Chromeleon CDS software
Use intuitive Chromeleon CDS software to control your entire chromatography lab. It is fully scalable from a single workstation to an enterprise-wide installation, controls over 350 modules from Thermo Scientific and many other vendors, and supports quantitative MS workflows for all separation techniques. Chromeleon CDS software reduces repetitive tasks and errors, making work faster and easier while ensuring reproducible, quality results.
- Thermo Scientific Chromeleon XPS Open Access software enables untrained users to use the full power of Chromeleon to test samples in a streamlined "walk-up" interface.
- Thermo Scientific eWorkflows simplifies and speeds up creation of sample sequences. If you need to jump-start method development, download ready-to-use eWorkflows from the Thermo Scientific AppsLab Library into the Chromeleon CDS.
- The Environmental Analysis Extension Pack is a full set of predefined templates and methods that allows you to perform GC-MS environmental analysis to quickly and easily calculate results and generate reports in a manner consistent with the requirements of the U.S. EPA.
TraceFinder software
Optimized for quantitation, TraceFinder software provides an array of tools that makes targeted and untargeted analyses in food, environmental, and forensic toxicology applications simple, fast, and productive. Customized templates, automatic report generation, a method development wizard and comprehensive database, speed up the development of sensitive, robust, and reproducible quantitation methods.
UNSTOPPABLE GC-MS analysis
Laboratories performing food, environmental, or forensic toxicology testing demand analytical systems that are unstoppable in every way. That’s the inspiration behind the Thermo Scientific ISQ 7000 single quadrupole GC-MS system. With UNSTOPPABLE sensitivity, ease of use and uptime, this truly scalable platform empowers you to become a real-life superhero. Now you can prevail over increasingly challenging regulatory requirements and productivity pressure.
UNSTOPPABLE sensitivity
Click image to enlarge
The ISQ 7000 GC-MS system delivers highest sensitivity, being able to reach detection limits as low as sub-femtogram-levels. Whether you run in selected ion monitoring (SIM) or full scan modes, you consistently achieve the required response as you analyze samples. Achieving low detection limits requires breaking noise-reduction boundaries. The ISQ 7000 GC-MS system does so with pre-filters having a unique ion path that neutrals cannot navigate.
Choose either the rugged Thermo Scientific ExtractaBrite ion source technology or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) source. Available in a dedicated system configuration, the AEI source allows you to drive down instrument detection limits and reduce time-consuming sample concentration steps.
UNSTOPPABLE uptime
Extended instrument uptime reduces turnaround time and overhead costs. Robust design ensures that your ISQ 7000 GC-MS system continues to produce the highest-quality results possible. Whether you select the ExtractaBrite or AEI ion source, you benefit from high matrix tolerance to minimize routine maintenance.
With NeverVent technology for the ExtractaBrite source, it’s possible to isolate the mass spectrometer from the gas chromatograph, allowing source cleaning, column replacement, or injector maintenance, without downtime for venting. This makes the ISQ 7000 a useful tool for eliminating waste and maximizing laboratory efficiency.
UNSTOPPABLE ease of use
The ISQ 7000 GC-MS system improves user experience with automated software tools to streamline instrument tuning, method development, targeted quantification, and untargeted screening workflows. The software also makes it easy to transition to the ISQ 7000 GC-MS system from other platforms by facilitating instrument familiarization.
AutoSIM and Timed-SIM (t-SIM) automate method development and optimization for targeted SIM workflows. Retention Time Alignment (RTA) allows you to set analyte retention times, and facilitate high-throughput work. Untargeted screening methods are likewise simplified. Mass spectral deconvolution unravels heavy co-elution by reconstructing clean mass spectra that are ready for library searching, identification, and confirmation. For any workflow, SmartTune simplifies tuning procedures and, if required, notifies the user of any necessary corrective actions.
Target analysis
Method development
Routine analysis
AutoSIM
AutoSIM allows you to acquire full-scan data, enter or import from external file (csv, Excel, LIMS database) your list of target analytes, and perform selection of the SIM ions from the FS data in a guided, automated fashion. A real time saver and productivity booster.
Timed-SIM method
Timed Acquisition (t-SIM) helps optimize the dwell times in SIM quantitation methods with large number of analytes, especially in case of co-elution, assuring the maximum sensitivity. However, a manual set up of t-SIM can be tedious. This is why AutoSIM is complementary to t-SIM, for a fully automated workflow.
Retention Time Alignment (RTA)
The new RTA tool uses Void Time and Retention Time of a reference substance to provide new carrier flow and pressure settings or new columns dimension settings to realign retention times of all the peaks of the chromatograms. This means that during a column change or trim, you can quickly re-align the retention times and return to collecting results.
Untargeted screening
Method development
Routine analysis
Full-scan acquisition
For untargeted analysis, leverage the easier and quick set up of a full-scan acquisition method, maintaining the analytical information of the entire mass range.
Mass spectral deconvolution
Unravel the heaviest co-elution of the TIC chromatogram by reconstructing clean mass spectra for heavy co-eluted compounds, ready for reliable library searching and ID confirmation.
Mass spectral deconvolution (continued)
SmartTune
SmartTune is the new simplified tuning tool for Thermo Scientific ISQ and TSQ instruments. This intuitive tool removes tuning complexity and ensures your system is performing at the level you require, ahead of running your samples. A simple guided interface efficiently checks and tunes the system, and intelligently eliminates any unnecessary steps in the process, resulting in faster tuning operations. If a problem is detected, SmartTune advises you on recommended corrective action. In addition, SmartTune allows user customizable targets to facilitate consistency in performance between analytical sequences.
UNSTOPPABLE scalability
Click image to enlarge
In an evolving world, it’s important to be prepared for the future. The fully scalable ISQ 7000 GC-MS system provides a upgrade path from basic to advanced configurations, allowing you to add capability if you need it. With five performance and price levels, and field-upgrade options, you can invest in fit-for-purpose solutions at the right cost and still expand your analytical capability in the future.
UNSTOPPABLE workflows
Pressure to increase productivity, and the growing list of compounds that laboratories must quantify and screen, necessitate workflow-driven software. Intuitive Thermo Scientific Chromeleon Chromatography Data System (CDS) software is available to streamline quantitative workflows. Download ready-to-use Thermo Scientific eWorkflows from the Thermo Scientific AppsLab Library to jump-start method development. For U.S. EPA-based environmental applications, the Environmental Analysis Extension Pack provides a set of GC-MS e-workflow and reporting templates.
- Fixed Calibration, Check Standards, QC Samples, Unknowns
- Tune Check, Calibration Curve, QC Samples
- Fixed Calibration, Check Standards, Injections for computing Minimum Detection Level (MDL)
- Fixed Calibration, Check Standards, Injections for performing method validation
UNSTOPPABLE GC-MS/MS analysis
Laboratories performing food, environmental, forensic toxicology and other routine testing demand analytical systems that are unstoppable in every way. That’s the purpose of the Thermo Scientific TSQ 9000 triple quadrupole GC-MS/MS system. This truly scalable platform delivers unprecedented sensitivity for targeted quantitation of trace and ultra trace-level compounds in complex sample matrices. Add unrivaled ease of use and uptime, and you become a real-life superhero empowered to prevail over increasingly challenging regulatory requirements and productivity pressure.
UNSTOPPABLE sensitivity
Click image to enlarge
The TSQ 9000 GC-MS/MS system is able to deliver sensitivity into the attogram range and best-in-class selected-reaction-monitoring (SRM) performance, so you consistently meet required detection limits for high capacity methods as you test samples.
Choose either the rugged Thermo Scientific ExtractaBrite ion source or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) source. Available in a dedicated system configuration, the AEI source provides highly efficient ionization and a more tightly focused ion beam to drive down instrument detection limits and reduce time-consuming sample concentration steps.
The Enhanced Velocity Optics Collision Cell (EvoCell) augments sensitivity and precision for complex methods. It can be used to increase the scope of SRM methods to fit a wider range of compounds and matrices, increase sample throughput by compressing GC time, or increase method resistance to matrix effects and retention time shifts.
UNSTOPPABLE uptime
Click image to enlarge
Extended instrument uptime reduces turnaround time. The TSQ 9000 GC-MS/MS system is designed specifically for complex sample matrices in high-throughput applications. Whether you select the ExtractaBrite or AEI ion source, you benefit from high matrix tolerance to minimize maintenance intervals.
NeverVent technology takes GC-MS/MS uptime to a new level. The vacuum probe interlock (VPI) with the ExtractaBrite source and V-Lock source plug, make it possible to isolate the vacuum system on the mass spectrometer, allowing source cleaning, and ion source and column changing, without downtime for venting. Now you can eliminate up to 98% of the downtime associated with routine GC-MS system maintenance.
UNSTOPABBLE ease of use
The TSQ 9000 GC-MS/MS system enhances user experience, learning, and ease of switching from other platforms with automated software for method development, routine operation, and targeted quantification workflows.
SIM Bridge, AutoSRM, and t-SRM automate development and optimization of SRM-based targeted workflows, allowing even less-experienced users to develop powerful MS/MS-based methods. Retention Time Alignment (RTA) adds an easy way to maintain retention times for high-throughput work. SmartTune simplifies instrument tuning and, if needed, informs the user of corrective actions, ensuring the system performs as required.
Method development
SIM Bridge
- The SIM Bridge tool allows SIM methods exported from other sources to be translated to the TSQ 9000 system method. Those SIM methods can be immediately run on the TSQ 9000 system or through AutoSRM to translate the SIM information into a powerful SRM method.
AutoSRM
- AutoSRM is your very own mass spectrometer method development expert integrated into your system. This software walks you through the development of fully optimized SIM target ions or SRM transitions in a very simple and efficient workflow. If you like to develop from your current SIM method, SIM Bridge streamlines the workflow by importing your method details. All together, it is full MS and MS/MS method development independence, even for the less experienced user.
Timed-SRM method
- As more compounds are added to a single run, managing acquisition windows becomes increasingly complex. The TSQ 9000 system dramatically reduces this complexity by automatically optimizing the targeting of a particular compound. Simply enter the retention time and the time required to capture the peak, and t-SRM takes care of the rest. This ensures that compound detection is optimized for maximum sensitivity, and more compounds can be added to the method without compromising the excellent sensitivity of each individual analyte. The mass spectrometer is not consuming valuable resources scanning for compounds at the times when those compounds are not eluting.
Routine analysis
Retention Time Alignment (RTA)
- The new RTA tool is a faster, more flexible and easier way to maintain retention times during routine operation of high-throughput GC-MS methods. The tool uses the measured void time of the column and the retention time of a reference substance to provide a new column length and internal diameter settings (or corrected pressure or flow value) to realign retention times of all the peaks of the chromatograms. This means that during a column change or trim, the user can quickly re-align their retention times and return to collecting results.
SmartTune
- SmartTune is the new simplified tuning tool for Thermo Scientific ISQ and TSQ instruments. This intuitive tool removes tuning complexity and ensures your system is performing at the level you require, ahead of running your samples. A simple guided interface efficiently checks and tunes the system, and intelligently eliminates any unnecessary steps in the process, resulting in faster tuning operations. If a problem is detected, SmartTune advises you on recommended corrective action. In addition, SmartTune allows user customizable targets to facilitate consistency in performance between analytical sequences.
UNSTOPPABLE scalability
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It’s difficult to predict the analytical challenges that lie ahead. The fully scalable TSQ 9000 GC-MS/MS system provides an upgrade path that enables basic to advanced configurations, allowing you to add capability when you need it.
UNSTOPPABLE workflows
Pressure to increase productivity, and the growing list of compounds that laboratories must quantify and screen, necessitate workflow-driven software.
Intuitive Thermo Scientific Chromeleon Chromatography Data System (CDS) software is available to support quantitative workflows, and Thermo Scientific eWorkflows can be added to simplify creation of analytical workflows. If you need to jump-start method development, download ready-to-use eWorkflows from the Thermo Scientific AppsLab Library.
- Fixed Calibration, Check Standards, QC Samples, Unknowns
- Tune Check, Calibration Curve, QC Samples
- Fixed Calibration, Check Standards, Injections for computing Minimum Detection Level (MDL)
- Fixed Calibration, Check Standards, Injections for performing method validation
Innovative MS technology future-proofs GC-MS investment
Innovative technologies applied to the Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems work together to deliver UNSTOPPABLE GC-MS system performance. You get best-in-class sensitivity, uptime, and ease of use, future-proofing your investment to address increasingly challenging regulatory requirements.
ExtractaBrite ion source
Part of Thermo Scientific NeverVent technology, the Thermo Scientific ExtractaBrite ion source technology delivers proven rugged electron impact (EI) and chemical ionization (CI) performance. The source is removable for maintenance or switching ionization modes without breaking vacuum. In addition, by exchanging the ion source with the V-Lock source plug, GC columns can be replaced without venting.
To protect analyte integrity and maximum robustness, the ExtractaBrite ion source is comprised of highly inert material. It is also heated throughout to prevent mass analyzer contamination and to ensure matrix tolerance for high-throughput work. As a result, there is never a need to heat or clean the quadrupoles.
Advanced Electron Ionization (AEI) source
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The ultra-robust, ultra-sensitive Advanced Electron Ionization (AEI) source is available in dedicated ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS system configurations. Highly efficient ionization, a tightly focused ion beam, and heating throughout the source reduce mass spectrometer contamination, extend system uptime, and lower instrument detection limits to unprecedented levels. With ultra-high sensitivity, the AEI source can also help reduce sample concentration steps and consequent matrix pressure on the analytical system.
EvoCell
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Part of the TSQ 9000 triple quadrupole GC-MS/MS system, Enhanced Velocity Optics Collision Cell (EvoCell) technology boosts sample throughput with very high selected-reaction-monitoring (SRM) transition speeds, providing enhanced precision and sensitivity for even the most complex methods. Timed-SRM (t-SRM) software automates optimization of SRM scheduling.
EvoCell technology can be used to increase the scope of SRM methods to fit a wider range of compounds and matrices, increase sample throughput by compressing GC time, or increase method resistance to interferences, matrix effects, and retention time shifts.
NeverVent technology
Patented Thermo Scientific NeverVent technology delivers UNSTOPPABLE GC-MS uptime. Used with the ExtractaBrite ion source, the vacuum probe interlock (VPI) and the V-Lock source plug isolate the vacuum region of the mass spectrometer from the gas chromatograph, allowing routine source cleaning, and ion source and column changing, without venting.
Dual filament
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The dual filament design extends instrument uptime. Both filaments produce similar analytical performance so you can switch from one to the other without impacting analytical performance. To simplify operation, the dual filament assembly is used for both EI and CI modes.
GC-MS transferline
Independently heated zones for transfer line, ion source, and ion optics help ensure that the system stays cleaner for a longer period of time.
The optimized GC-MS transferline evenly distributes heat across the length of the analytical column, ensuring that there are no hot or cold spots, which in turn delivers Gaussian peak shapes, even for high boiling point compounds.
Ion source probes
Optional ion source probes enable you to perform real-time MS and MS/MS experiments on solid samples with easy switching between EI and CI modes. Like the ExtractaBrite ion source, the probes can be removed without venting.
Available ion source probes:
Direct Insertion Probe (DIP) for rapid analysis of components in solid matrices.
Direct Exposure Probe (DEP) for rapid molecular weight confirmation of solids dissolved or suspended in liquid solvents.
MS software innovations advance method development
The Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems include a comprehensive set of software features for instrument tuning, and method development and optimization of targeted quantification and untargeted screening workflows. The software provides users with a seamless experience during the transition from other platforms.
AutoSIM and Timed-SIM
AutoSIM saves time during method set up. The software provides automated, user-selectable, criteria-guided development of SIM method from full scan data, either automatically acquired by AutoSIM or imported from external data files (CSV, Excel, LIMS database).
For maximum sensitivity, Timed-SIM (t-SIM) acquisition helps users optimize the dwell times used in SIM-based quantitation of large numbers of analytes, especially for co-eluting analytes. AutoSIM can be used together with t-SIM to completely automate workflows.
SIM Bridge and AutoSRM
SIM Bridge translates SIM methods from other sources into TSQ 9000 GC-MS/MS system methods. The SIM methods can then be immediately used as-is, or converted into more powerful SRM methods using AutoSRM.
AutoSRM walks users through selection of optimum SRM transitions for TSQ 9000 GC-MS/MS system methods. Together, SIM Bridge and AutoSRM enable even less-experienced staff to rapidly develop MS and MS/MS methods.
Timed-SRM
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As compounds are added to a method, managing acquisition-time windows becomes increasingly complex. For the TSQ 9000 GC-MS/MS system, t-SRM dramatically reduces this complexity by automatically optimizing the SRM parameters needed to attain sensitive detection and quantification. The user simply enters the retention time window for the target peak, and t-SRM takes care of the rest.
Retention time alignment
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Retention Time Alignment (RTA) is a fast, flexible, and easy way to maintain retention times during high-throughput GC-MS system operation. RTA uses the void time of the column and retention time of a reference substance to provide new column dimension settings, or to correct carrier gas pressure or flow values to realign chromatographic peaks. After a column replacement or trim, the user can quickly realign the retention time.
SmartTune
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SmartTune simplifies and speeds GC-MS instrument tuning and, if needed, recommends corrective actions. This helps ensure that your system performs at the levels you require for longer periods of time.
Step into GC 2.0
Boost productivity, accelerate response times, and lower your total cost of ownership with the Thermo Scientific TRACE 1310 Gas Chromatograph. Providing versatility and exceptional GC and GC-MS performance, it is an ideal choice for the Thermo Scientific ISQ 7000 GC-MS and TSQ 9000 GC-MS/MS systems. Tailor the TRACE 1300 Series Gas Chromatograph to your needs with its proprietary user-exchangeable Instant Connect injector and detector modules, and a range of Thermo Scientific autosamplers, columns, and consumables.
Instant connect injectors and detectors
Swapping Instant Connect modules is easy: Simply remove and replace three screws, which are accessible from the top of the GC system. The entire process takes under five minutes without requiring specialized service assistance. Interchangeable modularity provides maximum uptime by allowing offline cleaning and servicing of the modules.
- The Instant Connect SSL (Split/Splitless) injector features an optimized thermal profile specially developed to avoid sample discrimination in split and splitless mode, allowing the broadest range of analytes to be accurately injected.
- The Instant Connect PTV (Programmed Temperature Vaporizing) injector combines the "discrimination-free" performance of a cold injector with the robustness of a vaporizing injector. This injector is ideal for trace analysis in difficult matrices and thermally labile compounds.
- The Instant Connect Helium Saver Module is a proprietary split/splitless injector that greatly reduces helium consumption. Helium supplies the carrier gas flow to the capillary column, while nitrogen is used for all other injection processes, including septum purge, split, and sample vaporization.
- The Instant Connect-FID (Flame Ionization Detector) offers highest sensitivity and a wide dynamic range with rapid acquisition speed, making it ideal for extremely fast GC applications.
- The micro-volume Instant Connect-TCD (Thermal Conductivity Detector) is non-destructive and provides exceptional thermal stability, fast response, and exceptional sensitivity over the widest range of applications.
- The Instant Connect-ECD (Electron Capture Detector) is optimized for selective trace analysis of organohalogenated compounds, even in challenging sample matrices. Its miniaturized cell, equipped with a purged, removable anode, is designed to guarantee the utmost sensitivity while maximizing robustness.
- The Instant Connect-NPD (Nitrogen Phosphorous Detector) brings exceptional sensitivity and selectivity for the determination of nitrogen or phosphorous-containing organic compounds.
- The Instant Connect-FPD (Flame Photometric Detector) provides excellent sensitivity and response stability for demanding sulphur applications, as well as phosphorous or tin determinations.
Choice of autosamplers
To meet your automation needs, choose the Thermo Scientific AI/AS 1310 Series, TriPlus RSH, TriPlus 100 LS and TriPlus 300 HS autosamplers.
- The AI/AS 1310 Series Autosampler improves the consistency and quality of GC results. Engineered to stand up to the demands of any busy high-throughput lab, this autosampler helps you process more samples quickly and cost-effectively.
- A step ahead in automated sampling, TriPlus RSH Autosampler uses robotic sample handling to expand automation beyond liquid, static, and dynamic headspaces, as well as solid-phase micro extraction (SPME) injections. This system also enables automation of basic sample and standards preparation procedures such as dilution, internal standard addition, and derivatization. Improved precision and reproducibility, even for low injection volumes, produce higher quality results.
- The Triplus 100 LS Autosampler is a robotic platform ideal for high sample throughput when only liquid injection is required. Fully compatible with Triplus RSH liquid accessories, it features a vial capacity that is upgradable from 162 up to 624 vials, nano- to large-volume injection capabilities, and flexible injection modes.
- Automate and accelerate your analyses of organic volatiles. The TriPlus 500 GC Headspace Autosampler helps increase sample turnaround and lower overall cost per analysis. Based on Valve-and-Loop technology, this autosampler also ensures the highest data quality and full compliance with regulatory statutes.
High-performance Thermo Scientific chromatography columns and consumables
Get the most out of your GC-MS system by pairing it with advanced, high-performance Thermo Scientific columns and consumables. Our wide range of consumables and accessories offer customers applications-focused solutions in the environmental, food safety, toxicology, clinical, petrochemical, pharmaceutical, and general analytical industries.
- Thermo Scientific TraceGOLD Columns—low bleed, high reproducibility
- Consumables tested and certified with TRACE 1300 Series GC systems
- Vials guaranteed for Thermo Scientific Autosampler systems
- Thermo Scientific GFM Pro Gas Flowmeter and Thermo Scientific GOLD Pro Gas Leak Detector for system installation and maintenance
- Derivatization reagents and derivatization-grade solvents
UNSTOPPABLE workflows
Streamlined, workflow-driven software solutions such as Thermo Scientific Chromeleon Chromatography Data System (CDS) and TraceFinder software empowers your lab to successfully address productivity needs and increasingly complex regulatory requirements.
Chromeleon CDS software
Use intuitive Chromeleon CDS software to control your entire chromatography lab. It is fully scalable from a single workstation to an enterprise-wide installation, controls over 350 modules from Thermo Scientific and many other vendors, and supports quantitative MS workflows for all separation techniques. Chromeleon CDS software reduces repetitive tasks and errors, making work faster and easier while ensuring reproducible, quality results.
- Thermo Scientific Chromeleon XPS Open Access software enables untrained users to use the full power of Chromeleon to test samples in a streamlined "walk-up" interface.
- Thermo Scientific eWorkflows simplifies and speeds up creation of sample sequences. If you need to jump-start method development, download ready-to-use eWorkflows from the Thermo Scientific AppsLab Library into the Chromeleon CDS.
- The Environmental Analysis Extension Pack is a full set of predefined templates and methods that allows you to perform GC-MS environmental analysis to quickly and easily calculate results and generate reports in a manner consistent with the requirements of the U.S. EPA.
TraceFinder software
Optimized for quantitation, TraceFinder software provides an array of tools that makes targeted and untargeted analyses in food, environmental, and forensic toxicology applications simple, fast, and productive. Customized templates, automatic report generation, a method development wizard and comprehensive database, speed up the development of sensitive, robust, and reproducible quantitation methods.
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