Why choose a Vanquish HPLC or UHPLC system?

Vanquish HPLC and UHPLC systems offer:

  • A broad range of instruments to serve every analytical need, from small to large molecules, from complex to simple mixtures
  • Innovative technology, intuitive operation, and easy maintenance
  • Analytical precision, including unsurpassed peak area and retention time precision
  • Ideal fluidic connections with nearly-zero dead volume Thermo Scientific Viper fingertight fittings
  • Convenient instrument control with the easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools
  • Instrument control of Vanquish Horizon and Vanquish Flex UHPLC systems under Waters Empower 3 CDS software with Thermo Scientific Standard Instrument Integration (SII)
Vanquish HPLC and UHPLC Systems

Learn how revolutionary HPLC technology from Thermo Fisher Scientific has changed and improved the science of HPLC over the last 35+ years.

Meet the Vanquish HPLC and UHPLC systems

Choose from these four modular systems to meet your analytical and performance requirements. In addition to these base systems, we offer several application-specific systems that are individually configured from the modules of these systems.

Vanquish Core HPLC Systems
Vanquish Core HPLC Systems
Vanquish Flex UHPLC Systems
Vanquish Flex UHPLC Systems
Vanquish Horizon UHPLC Systems
Vanquish Horizon UHPLC Systems
Vanquish Neo UHPLC System
Vanquish Neo UHPLC System
 Download brochure Download brochure Download brochure Download brochure
Typical applications
Achieve dependable traditional or routine HPLC analysis with Vanquish Core HPLC systems. These systems remove disruptions to your analyses and empower operators to deliver continuous results. Regardless of the systems your laboratory currently uses, switching to the Vanquish Core HPLC is simple and seamless.Gain the flexibility to run both HPLC and UHPLC on a single system with Vanquish Flex UHPLC systems. These systems offer flexible method development to accommodate all applications. Vanquish Flex UHPLC systems offer outstanding performance for targeted UHPLC and LC-MS workflows.Get top performance and resolution for demanding separations with the Vanquish Horizon UHPLC systems. These systems provide unrivaled performance and throughput for your most complex and difficult samples. They allow for smaller particles and column dimensions to be run with greater confidence for the most demanding UHPLC and LC-MS workflows.Pursue the next scientific breakthrough with the best performance, productivity, and usability in a nano-, capillary-, and micro-flow UHPLC systems. The Vanquish Neo UHPLC system combines an unrivaled degree of innovation to deliver 24/7 reproducible separations of complex mixtures at maximum performance for a variety of high-sensitivity LC-MS workflows.
Pump options
Binary, Quaternary, Dual and IsocraticBinary, Quaternary and DualBinaryBinary
System pressure
Half circle
Up to 700 bar
3/4 circle
Up to 1000 bar
Full circle
Up to 1500 bar
Full circle
Up to 1500 bar
Flow range
0.001 - 10 mL/min0.001 - 8 mL/min0.001 - 5 mL/min1 nL/min - 100 μL/min


Application-specific LC systems

In addition to our three base systems, the modules from the Vanquish Core, Vanquish Flex and Vanquish Horizon systems can be individually configured to create systems for specific applications. We offer several application-specific HPLC and UHPLC systems for applications ranging from dual LC and LC-MS to those featuring online sample preparation or heart-cutting 2D-LC workflows. These modular systems can be individually configured using Vanquish Core HPLC, Vanquish Flex UHPLC or Vanquish Horizon UHPLC components.

Vanquish Duo UHPLC Systems

Increase your productivity, system up-time, and sample knowledge for a faster return on investment with the Vanquish Duo HPLC and UHPLC systems. These systems expand the benefits of the Vanquish platform with four workflows (Dual LC, Tandem LC or LC-MS, Dual LC-MS, and Inverse Gradient LC). Each Vanquish Duo HPLC or UHPLC system features an independent separate second flow path within the integrated system allowing you to save time and cost per sample with no need for additional bench space, and without compromising performance, robustness, or ease of use.

Learn more  Download brochure

Vanquish Online 2D-LC Systems

Add more separation power and gain more confidence in your sample analysis using 2D-LC (LC-LC). Four different Vanquish Online 2D-LC systems enable online sample preparation, multiple heart-cutting modes and even include a system that offers the flexibility to switch between gaining the confidence of 2D-LC and the productivity of Dual LC. All four Vanquish Online 2D-LC systems allow you to explore your sample in depth.

Learn more

Vanquish HPLC and UHPLC learning materials


Want to learn more? – Speak to a sales specialist

Style Sheet for Global Design System