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Downstream Educational Resources
We have developed multiple solutions for downstream buffer preparation and supply, and are integrating single-use technologies into downstream workflows to drive process simplification. Please find below all of the latest resources on downstream processing.
Advancing Microbial Bioproduction Webinar
Learn how to benefit from recent technology advances to successfully develop your bioprocess.
Early process development options and speed to clinic
Learn how some key early technology choices can positively impact your bioprocess development agility and time to clinic.
How to ensure quality and compliance in implementation of single use systems
Watch this educational webinar and discover valuable risk mitigation strategies addressing important issues such as integrity or particulates, both in the area of rigid or flexible single-use systems.
Vaccines Downstream Innovations Webinar
Learn how to benefit from recent technology advances to develop or improve your vaccine’s downstream bioprocess, either microbial or animal cells based.
AAV manufacturing for clinical and commercial gene therapies
In this webinar, Thermo Fisher Scientific describe how they are mobilizing to meet rapidly growing demand for AAV vector from both technology development and manufacturing strategy viewpoints.
AAV downstream processing for industrial scale production
Watch this educational webinar and learn about the benefits of implementing affinity chromatography in the downstream purification of viral vectors
Clearing the way for viral clearance
Discussed here are results from a series experiments in which in-process mAb material was spiked with MVM-MVP and processed through Anion Exchange and Cation Exchange.
Development and Validation of Quantitative Real-Time PCR for the Detection of Residual HEK-293 Host Cell DNA
In this webinar, we share the development and validation of a new, and highly sensitive and accurate solution for detecting and quantifying residual HEK293 host cell DNA to help meet regulatory requirements.
Global Regulators' FAQs on CMC in IND/BLA Filing
Hear from our experts: A retrospective look at past Mycoplasma validation queries and responses
Platform Purification Approaches for the Production of Complex Biologics
This webinar focuses on POROS Ion Exchange and Hydrophobic Interaction chromatography resins, addressing purification challenges of today’s biomolecules.
Validation Guidance for Residual Host Cell DNA Testing
Watch this webinar and learn more about validation of a qPCR assay for residual host cell DNA quantitation.
Thermo Scientific Bioprocess Equipment and Automation Solutions from R&D to Production
Research and development, process development, and pilot plants involved in scale-up and technology transfer can face significant setbacks such as time and data loss due to a lack of efficient, traceable data transfer.
Thermo Scientific BioProcess Container (BPC) unpacking and installation
This video is part 1 of 2 videos that cover the unpacking and inspection of Thermo Scientific BioProcess Containers (BPCs).
Thermo Scientific BioProcess Container (BPC) unpacking and installation
This video is part 2 of 2 videos that cover the unpacking and inspection of Thermo Scientific BioProcess Containers (BPCs).
6 critical considerations for bioprocess lab equipment selection
As the market develops a need for more open and flexible systems, special attention should be paid to how your bioprocess equipment meets both present and future facility and process requirements.
Affinity chromatography accelerates viral vector purification for gene therapies
A case study demonstrates that affinity chromatography can offer efficiency and scalability for gene therapy manufacturing using viral vectors.
Affinity tags head toward the vaccination clinic
Protein purification is a tricky business. Read the article to find out more on affinity chromatography purification.
Automation and Data Management Across Biomanufacturing Workflows
As the market develops a need for more open and flexible systems, special attention should be paid to how your bioprocess equipment meets both present and future facility and process requirements.
Automation, modularity allow mAb biotech to cut scale-up time
Original developers of biosolutions and products, especially those facing the debut of biosimilars in core markets, have an urgent imperative to reduce manufacturing costs via increased productivity and yields. In turn, this drives a wide range of business decisions, including capital investment, process choices and design, and equipment selection.
Bispecifc Antibodies Exploits Differential Chain Expression and Affinity Capture
Generation of bispecifc antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain.
Development of purification steps for several AAV serotypes using POROS CaptureSelect AAVX affinity chromatography
Learn more about Capture Select technology minimizing the steps in the purification process.
Enabling cell & gene therapy raw materials standardisation
The quality of raw materials needs to be considered according to the stage of development of the cell or gene therapy.
Improving aggregate removal to enhance clinical manufacturing of MAbs
Hydrophobic interaction chromatography (HIC) in flow-through mode offers a more efficient and cost-effective polishing/purification process.
Labtainer Pro BioProcess Container extractables profile
Single-use technology (SUT) products are beneficial in the manufacturing of vaccines and biologics.
Labtainer Pro BPC quality and integrity testing
Thermo Scientific Labtainer Pro BPC was developed to meet a variety of bioproduction workflow needs.
Meeting the global demand for non-monoclonal antibody biosimilars
Biologics have transformed patient treatment by offering new and effective medicines for a range of chronic and acute conditions.
Microbial Testing: Five Myths Vs. Reality
Five Myths Vs. Reality for Microbial testing.
Novel Hydrophobic Interaction Chromatography Resins
Using the POROS resins, a HIC step can be easily implemented resulting in increased yields and reduced processing times through effective and efficient removal of impurities.
Overcoming downstream purification challenges for viral vector manufacturing
Enabling advancement of gene therapies in the clinic.
Quantifying residual DNA using qPCR
Find out more about the development of a novel residual DNA assay for HEK-293.
Rapid Implementation of Novel Affinity Purification
Manufacture of Commercial-Scale Next-Generation Antibody Therapies
Rapid implementation of novel affinity purification
Production processes have become more efficient because common purification processes are being used across structurally similar MAbs during key steps of process development and manufacturing.
Regulatory FAQs for cell and gene therapy
This article focuses on key regulatory considerations and requirements across the cell and gene therapy raw and starting materials area.
Upstream and downstream solutions for AAV manufacturing
With the advancement of gene delivery vectors and gene editing technologies, cell and gene therapies are a very real solution to many previously untreatable or difficult to treat diseases
Validated shipping of filled Labtainer Pro BioProcess Containers
Growing competition across the biomanufacturing industry is resulting in a greater need for efficiency and speed at all stages of development and manufacturing. Read the full application note.
Bioprocessing resources
Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:
Style Sheet for Global Design System