SelectScreen Lead Optimization Services offer drug discovery researchers a faster method for narrowing the selection of drug candidates for downstream selectivity profiling and further investigation. The assays we perform can be target-based, investigating changes to function, or phenotypic, examining the biologic response that a compound has on cells.
Our in-house team can run biochemical and cellular assays to optimize drug potency and generate dose-response curves, identifying the compounds that cause the desired effect in your target of interest. Choose from our broad portfolio of assay technologies*, or provide your own targets/assays and we can perform validation.
|Biochemical Assays||Cellular Assays|
*We also can perform validation and screening of client-provided assays that do not utilize our technologies, or build a custom assay to fit our specific screening needs. If you would like to request a technology outside of the Thermo Fisher Scientific™ portfolio, send us an inquiry.
Lead optimization services offer an advantage over broader screening because we can deliver data quickly, typically in 3 to 5 days (depending on the assay), and at lower cost than large panel screens. This enables you to make chemistry decisions more rapidly and move leads forward.
|Broad profiling||Lead optimization|
|Number of targets/assays||Many||Few|
|Mode||Single point with dose-response curve follow-up||Dose-response curves|
|Submission schedule||On demand||Weekly schedule|
|Client commitment||On demand||6+ months|
|Turnaround time||Avg. 4 to 8 days||Avg. 2 to 5 days|
After leads are optimized, top drug candidates can be carried forward for selectivity profiling to determine specificity and downstream impact in preparation for possible future clinical testing.
To discuss your lead optimization program needs with us, send us an inquiry
From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.
For Research Use Only. Not for use in diagnostic procedures.